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M2 GI > H2 Blockers and PPIs > Flashcards

H2 Blockers and PPIs Flashcards

1
Q

What is Cimetidine classified as?

A

Histamine H2 receptor antagonist

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2
Q

What is Cimetidine’s mechanism of action?

A

Blocks histamine H2 receptors and decreases gastric secretion

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3
Q

What are H2 Blockers route of administration?

A

Oral or I.V.

-Also, injection for Cimetidine

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4
Q

What are the side effects of Cimetidine?

A
  • Gynecomastia with long-term use

- Impotence for some

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5
Q

What happens when you take both an H2 Blocker and a PPI?

A

Stop nocturnal acid breakthrough

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6
Q

What drug classification is Omeprazole?

A

Proton Pump Inhibitor

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7
Q

What is Omeprazole’s mechanism of action?

A

Inhibits H+/K+ pump (proton pump) in the gastric parietal cells

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8
Q

What is the route of administration for the PPIs?

A

Oral

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9
Q

What are the contraindications of Omeprazole?

A
  • increase concentrations of diazepam, warfarin, and phenytoin by decreasing their clearance by the liver
  • PPIs can reduce absorption of ketoconzole and increase absorption of digoxin
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10
Q

What are the side effects of Ranitidine?

A

Rare : agitation, anemia, confusion, or depression

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11
Q

What are the side effects of Omeprazole?

A

-Diarrhea, nausea, skin rash, dizziness

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12
Q

What is the side effect of Rabeprazole?

A

Headache

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13
Q

What is the classification of Sucralfate?

A

Mucosal Protective agent

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14
Q

What is the mechanism of action for Sucralfate?

A

binds selectively to necrotic tissue to form a barrier against gastric acid

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15
Q

What is route of administration for Sucralfate?

A

Oral

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16
Q

What are the contraindications for Sucralfate?

A
  • can decrease absorption of cimetidine, ciprofloxacin, digoxin, ofloxacin, ranitidine if given simultaneously with sucralfate
  • grapefruit promotes absorption of Al in sucralfate which is problem in patients with renal problems
17
Q

What are the side effects associated with Sucralfate?

A

Constipation, diarrhea, flatulence, dry mouth, nausea

M2 GI (2 decks)

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