Glucocorticoides Flashcards

0
Q

Efectos de los efectos Genómicos

A

Transrepresión y Transactivación

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1
Q

Cuales son los mecanismos de acción de los GC (describir)

A

Genómicos y No Genómicos

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2
Q

Sobre quién actúa la transrepresión

A

Sobre el NF-kB y AP-1 (inhibición)

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3
Q

Sobre quien son los efectos finales de los GC

A

Leucocitos y citocinas

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4
Q

Parte principal de los efectos no Genómicos

A

Apoptosis

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5
Q

Equivalencia y actividad relativa de prednisona

A

GC5
ActR GC 4
ActR MC 0.6

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6
Q

Administración del Acetato de Metilprednisolona

A

IM o Intraarticular

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7
Q

Importancia de los GC fluorinados y cuales son

A

(Dexa y betametasona)

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8
Q

Dosis baja de GC

A

< ó= 7.5 mg equivalente a prednisona al día

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9
Q

Dosis alta de GC

A

> 30-100 mg/día del equivalente de prednisona

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10
Q

Dosis que ejercen efectos Genómicos

A

Dosis bajas y altas

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11
Q

Dosis de los efectos no Genómicos

A

Muy altas o a pulsos

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12
Q

Cortisol promedio al día

A

20-30 mg/día

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13
Q

Croaríais en estrés al día

A

300-400 mg/día

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14
Q

Perspectivas a futuro de los GC a

A

SEGRA y Formulaciones Liposomales

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