Glomerular Filtration 3

Question 1

What is congenital nephrotic syndrome

Answer 1

Leaking of proteins due to damage in slit diaphragm

Question 2

GFR is dependent on

Answer 2

Kf (SA and thickness) x net filtration pressure

Question 3

Is inulin bound to proteins

Answer 3

No

Question 4

GFR _____ clearance of INU

Answer 4

Equals

Question 5

Why is calculating inulin clearance not practical

Answer 5

Requires cathederization and expensive

Question 6

80% of creative is found in urine is _________, 20% found in urine is from _________

Answer 6

Filtration, reabsorbtion

Question 7

T/F P creatine is used clinically to test for kidney function

Answer 7

True

Question 8

Mesangial cells have what kind of mechanism

Answer 8

Myogenic

Question 9

T/F Major changes in arterial pressure significantly impacts renal plasma flow and GFR

Answer 9

False, MAP does not make a big impact on filtration

Question 10

How does myogenic auto regulation work

Answer 10

An increase in the pressure stretches blood vessels, membranes depolarate and Ca++ causes smooth muscle contraction

Question 11

What is the result of NaCl in DCT with high GFR

Answer 11

High NaCL

Question 12

What is the effect of adenosine, angiotensin II, EPI, NE, NSAIDS, and ADH on AA

Answer 12

Vasoconstriction

Question 13

What it’s the effect of PGE2 and PGI2, histamine on AA

Answer 13

Vasodilation

Question 14

What does angiotensin II at low does promote? At high dose?

Answer 14

Constriction at EA, Constriction at AA and EA

Question 15

What does prostaglandin cause

Answer 15

Dilation of afferent and efferent arterial
(Vasodialator)

Increases renal plasma flow, but also reduces outlet pressure. Doesn’t increase GFR much

Question 16

What are NSAIDS do to prostaglandins

Answer 16

Cause them to go down, not able to vasodilator

Question 17

What does Atrial neurotic peptide (ANP) do

Answer 17

Decrease resistance in afferent, increase resistatence in efferent

Tries to decrease blood volume

Question 18

What is the affect of sympathetics on GFR

Answer 18

Increases resistance in afferent

If you need to fight or flight, that isn’t a time to be making urine

Question 19

What does low level angiotensin do

Answer 19

Step on hose outlet

increase GFR, increases absorption too

Question 20

What is a moderate increase in angiotensin do

Answer 20

Constrict to the efferent and afferent

Question 21

What is the filtration load

Answer 21

GFR x plasma concentration

Question 22

Angiotensin II is a

Answer 22

Vasodialator

Question 23

RAAS is the best known hormonal system involved in regulating

Answer 23

Na

Question 24

What does aldosterone do

Answer 24

Increases Na Reabsorption by DCT

Question 25

Where is ACE expressed

Answer 25

In all epethelial lining, but most concentration in the lungs