GIM (Genetics, Stats, Ethics, Drugs, Misc)

Question 1

Periodic paralysis

Answer 1

Periodic paralysis (PP)

• Characterized by episodes of painless muscle weakness
• May be precipitated by heavy exercise, fasting, or high-carbohydrate meals (often associated with an increased release of epinephrine or insulin)
• Attacks occur suddenly with generalized weakness. Consciousness is preserved and bulbar and respiratory muscles are only mildly affected, if at all.
• Here’s a good summary table:

Question 2

Neurofibromatosis (NF)

Answer 2

Defn: autosomal dominant disorder Sx: Findings: diagnostic criteria Mgmt: manage complications Note: renal vascular hypertension may be seen (excise lesion)