General Pharm- Parasympathetic/Cholinergic Receptors

Question 1

Function of M1 Receptors

Answer 1

IN CNS- class q
Mediates Higher cognitive functions
Stimulates enteric nervous system

Question 2

Function of M2 Receptors

Answer 2

IN THE HEART - class I
Lower Heart rate and contractility of atria

Question 3

Function of M3 Receptors

Answer 3

GLANDS AND SMOOTH MUSCLE

• Increase exocrine gland secretions
• Increase gut peristalsis
• Increase bladder contraction
• Bronchoconstriction
• Increase pupillary muscle sphincter contraction (miosis)
• Ciliary muscle contraction (accommodation)
• Increase insulin release
• Lower BP and cereal perfusion

Question 4

M3 Receptors action

Answer 4

Promote synthesis of Nitric Oxide which leads to smooth muscle relaxation and vasodilation
and muscle contraction in other areas

Question 5

M3 Receptor agonists

Answer 5

Acetylcholine, Muscarine, Carbachol

Question 6

M3 Receptor Antagonists

Answer 6

Atropine