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Neoplasia > General Neoplasia > Flashcards

General Neoplasia Flashcards

1
Q

Down’s

A

ALL,AML

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2
Q

Xeroderma pigmentosum, albinism

A

Melanoma, basal cell carcinoma, and especially squamous cell carcinoma of skin

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3
Q

Chronic atrophic gastritis, pernicious anemia, post surgical gastric remnants

A

Gastric adenocarcinoma

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4
Q

Tuberous sclerosis (facial angiofibroma, seizures, mental retardation

A

Giant Cell astrocytoma, renal angiomyolipoma, and cardiac rhabdomyoma

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5
Q

Actinic keratosis

A

squamous cell carcinoma of skin

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6
Q

Barrett’s esophagus (chronic GI reflux)

A

esophageal adenocarcinoma

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7
Q

Plummer-Vinson syndrome (decreased iron)

A

Squamous cell carcinoma of esohagus

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8
Q

Cirrhosis (alcoholic, HepB or C)

A

Hepatocellular carcinoma

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9
Q

Ulcerative collitis

A

Colonic adenocarcinoma

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10
Q

Paget’s disease of bone

A

secondary osteosarcoma and fibrosarcoma

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11
Q

Immunodeficiency states

A

Malignant lymphomas

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12
Q

AIDS

A

Aggressive malignant lymphomas (non-Hodgkin’s) and Kaposi’s sarcoma

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13
Q

Autoimmune disease (Hashimoto’s thyroiditis, maysthenia gravis)

A

Lymphoma

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14
Q

Acanthosis nigricans (hyperpigmentation and epidermal thickening)

A

Visceral malignancy (stomach, lung, uterus)

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15
Q

Dysplastic nevus

A

Malignant melanoma

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16
Q

Radiation exposure

A

Leukemia, sarcoma, papillary thyroid cancer, breast cancer

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17
Q

abl

A

CML, tyrosine kinase; OG

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18
Q

c-myc

A

Burkitt’s lymphoma, transcription factor; OG

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19
Q

bcl-2

A

Follicular and undifferentiated lymphomas, anti-apoptosis; OG

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20
Q

HER2/neu (c-erbB2)

A

Breast, ovarian, and gastric carcinomas, tyrosine kinase; OG

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21
Q

ras

A

Colon cancer, GTPase; OG

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22
Q

L-myc

A

Lung tumor, transcription factor; OG

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23
Q

N-myc

A

Neuroblastoma, trasncription factor; OG

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24
Q

ret

A

MEN 2A and 2B, Tyrosine kinase; OG

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25
Q

c-kit

A

GIST, cytokine receptor; OG

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26
Q

Rb

A

TS; retinoblastoma, osteosarcoma: inhibits E2F and blocks G1 to S

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27
Q

p53

A

TS; most cancers, Li Fraumeni: trasncription factor for p21 and blocks G1 to S

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28
Q

BRCA1

A

TS; breast and ovarian: DNA repair protein

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29
Q

BRCA2

A

TS; breast and ovarian: DNA repair protein

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30
Q

p16

A

TS; melanoma

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31
Q

BRAF

A

TS; melanoma: B-raf

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32
Q

APC

A

TS; colorectal cancer (associated with FAP)

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33
Q

WT1

A

TS; Willms’ Tumor (nephroblastoma)

34
Q

NF-1

A

TS; NeuroFibromatosis type 1: RAS GTPase activating proten (RAS-GAP)

35
Q

NF-2

A

TS; NeuroFibromatosis type 2: Merlin (schwannomin) protein

36
Q

DPC4

A

TS; Pancreatic Cancer (Deleted in Pancreatic Cancer)

37
Q

DCC

A

TS; Colon cancer (Deleted in Colon Cancer)

38
Q

PSA

A

use to follow prostate cancer

39
Q

Prostatic acid phosphatase

A

prostate carcinoma

40
Q

CEA

A

CarcinoEmbryonicAntigen, nonspecific. Produced by 70% of colorectal and pancreas cancers. Also gastric, breast, medullary thyroid carcinomas

41
Q

alpha-fetoprotein

A

fetal albumin. Hepatocellular carcinoma, nonseminomatos germcell tumors

42
Q

beta-hCG

A

Hydatidifrom moles, choriocarcinomas (gestational trophoblastic disease)

43
Q

CA-125

A

ovarian cancer

44
Q

S-100

A

melanoma, neural tumors, schwannomas

45
Q

AlkPhos

A

mets to bone, liver, or Paget’s of bone

46
Q

Bombesin

A

Neuroblastoma, lung, gastric cancer

47
Q

TRAP

A

Hairy Cell leukemia (a B-cell neoplasm)

48
Q

CA-19-9

A

Pancreatic adenocarcinoma

49
Q

Calcitonin

A

Medullary thyroid carcinoma

50
Q

HTLV-1

A

Adult T-cell leukemia/lymphoma

51
Q

HBV, HCV

A

Hepatocellular carcinoma

52
Q

EBV

A

Burkitt’s Hodgkin’s, nasopharyngeal carcinoma (China), CNS lymphoma (immune compromise)

53
Q

HPV

A

cervical (16,18) penile/anal, upper respiratory SCC

54
Q

HHV-8

A

Kaposi’s, body cavity fluid B-cell lymphoma

55
Q

H. pylori

A

GASTRIC adenocarcinoma and lymphoma

56
Q

Schistosoma heamatobium

A

bladder cancer

57
Q

Clonorchis sinensis

A

cholangiocarcinoma

58
Q

Aflatoxins (aspergillus)

A

Hepatocellular carcinoma

59
Q

Vinyl chloride

A

Liver angiosarcoma

60
Q

Carbon tetrachloride

A

Liver centrolobular necrosis, fatty change

61
Q

Nitrosamines (smoked food)

A

Gastric cancer

62
Q

Cigarette smoke

A

SCC of larynx and lung, small cell of lung, renal cell carcinoma, transitional cell carcinoma, pancreatic adenocarcinoma

63
Q

Asbestos

A

Bronchogenic carcinoma > mesothelioma

64
Q

Arsenic

A

SCC of skin, Angiosarc of liver

65
Q

Naphthaline (analine dyes)

A

Transitional cell carcinoma

66
Q

Alkylating agents

A

Leukemia

67
Q

Cushing’s syndrome

A

ACTH or ACTH-like peptide, Small Cell Lung Cancer

68
Q

SIADH

A

ADH, Small Cell lung cancer and intracranial neoplasms

69
Q

PTHrP

A

Hypercalcemia, squamous of lung, renal cell, breast

70
Q

1,25-(OH)2 D3

A

Hypercalcemia:Hodgkin’s lymphoma, some non-Hodgkin’s lymphoma

71
Q

EPO

A

polycythemia: renal cell, hemangioblastoma, hepatocellular, pheo

72
Q

Lambert-Eaton syndrome (muscle weakness)

A

Ab anti- presynaptic Ca++ channels at NMJ: Small Cell Lung cancer

73
Q

Psammoma bodies

A

Papillary (thyroid), Serous (ovary), Meningioma, Mesothelioma

74
Q

Top 3 Male incidence

A

Prostate, Lung, Colon

75
Q

Top 3 Female incidence

A

Breast, Lung, Colon

76
Q

Top 2 Mortality Male

A

Lung, Prostate

77
Q

Top 2 Mortality Female

A

Lung, Breast

78
Q

Mets to brain

A

Lung>breast>GU>osteosarc>melanoma>GI

79
Q

Mets to Liver

A

Colon»stomach>pancreas

80
Q

Mets to bone

A

prostate/breast>lung>thyroid,testes

Neoplasia (1 decks)

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