General immunospression Flashcards
1
Q
Name examples of general immunosupressants?
A
Corticosteroids
- Prednisolone
Dexamethosone
2
Q
What is the mechanism of action?
A
- inhibits inflammatory response
2. reduces cytokine expression by preventing gene transcription
3
Q
How are corticosteroids normally used?
A
- typically acutely
2. not suitable for prolonged use secondary to side effects
4
Q
What does the acronym CUSHINGOID MAP stand for?
A
- Cataracts
- Ulcers
- Striae
- Hypertension
- Infection risk
- Necrosis of bone
- Growth restriction
- Osteoporosis
- Increased intra cranial pressure
- Diabetes mellitus
- Myopathy
- Adipose tissue hypertrophy
- Pancreatitis
5
Q
How should corticosteroids be withdrawn?
A
- if on corticosteroids > 3 weeks there is a risk of adrenal supression
- patients will need gradual withdawl
6
Q
What else is prescribed alongside corticosteroids?
A
- PPI
2. Bone protection - bisphosphonates
