Gastrointestinal Stromal Tumor Flashcards

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1
Q

Most common mesenchymal tumor of abdomen

A

Gastrointestinal stromal tumor

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2
Q

Most common location of gist

A

Stomach

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3
Q

Carney triad

A
  1. Gastric gist
  2. Paraganglioma
  3. Pulmonary chondroma
    Seen in young females (non-hereditary)
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4
Q

Associated gene

A

NFT 1 (neurofibromatosis 1)
Kit (tyrosine kinase) gain of function mutation
Platelet derived growth factor receptor (pdgfra)

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5
Q

Cells of origin of gist

A

Interstitial cells of cajal , located in muscularis proprie which act as pacemaker of gut peristalsis

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6
Q

Pathogenesis

A

Kit → produce intracellular signals → activate Ras and AK T pathway → promote tumor cell proliferation

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7
Q

IHC and most useful diagnostic marker

A

Kit

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8
Q

Microscopy

A

Spindle cells or epitheloid cells

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9
Q

Clinical features

A

Mucosal ulcers and blood loss

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