Gastrointestinal Stromal Tumor Flashcards
1
Q
Most common mesenchymal tumor of abdomen
A
Gastrointestinal stromal tumor
2
Q
Most common location of gist
A
Stomach
3
Q
Carney triad
A
- Gastric gist
- Paraganglioma
- Pulmonary chondroma
Seen in young females (non-hereditary)
4
Q
Associated gene
A
NFT 1 (neurofibromatosis 1)
Kit (tyrosine kinase) gain of function mutation
Platelet derived growth factor receptor (pdgfra)
5
Q
Cells of origin of gist
A
Interstitial cells of cajal , located in muscularis proprie which act as pacemaker of gut peristalsis
6
Q
Pathogenesis
A
Kit → produce intracellular signals → activate Ras and AK T pathway → promote tumor cell proliferation
7
Q
IHC and most useful diagnostic marker
A
Kit
8
Q
Microscopy
A
Spindle cells or epitheloid cells
9
Q
Clinical features
A
Mucosal ulcers and blood loss
