Gastroenterology Flashcards
1
Q
Which HLA gene does coeliac disease have a strong association with?
A
HLA-DQ2 (present in ~95% of patients)
2
Q
Oesophagus epithelium
A
Stratified squamous epithelium
3
Q
What is the most common cause of duodenal ulcers?
A
H. pylori infection (accounts for >75% of duodenal ulcerations)
4
Q
Which cells are targeted by autoantibodies in pernicious anaemia?
A
Gastric parietal cells (which secrete intrinsic factor)
5
Q
What are the most common nutritional deficiencies seen with Coeliac Disease?
A
B12, iron and folate
6
Q
What metaplasia is seen in Barrett’s oesophagus?
A
Change to columnar epithelium.
Increases risk of adenocarcinoma
7
Q
What is secreted by chief cells?
A
Pepsin
