Gamma-Glutamyl Transferase

Question 1

What are the GGT normal RI for adults > 45 and children?

Answer 1

8-38 units/l

Question 2

What are the GGT normal RI for adults < 45?

Answer 2

5-27 units/l

Question 3

What are the GGT normal RI for elderly?

Answer 3

Slightly higher than adults over 45

Question 4

What are the indications for GGT testing?

Answer 4

1. Sensitive indicator for hepatocellular disease
2. MOST sensitive liver enzyme for detecting
   A. Biliary obstruction
   B. Cholangitis: inflammation of the common bile duct
   C. Cholecystitis: inflammation of the gall bladder
   D. Alcohol abuse

Question 5

What is the clinical significance of GGT?

Answer 5

Involved in transfer amino acids and peptides across cell membrane

Question 6

Where are the highest concentrations of GGT?

Answer 6

Liver

Biliary tract

Question 7

What conditions are asst. with increased GGT?

Answer 7

1. Liver disease
A. Hepatitis
B. Cirrhosis
2. Hepatic tumor or mets
3. Alcohol ingestion
4. EBV: splenomegaly and hepatomegaly