Gaba and Glutamate

Question 1

What is the long form of GABA?

Answer 1

GAMMA - AMINOBUTYRIC ACID

Question 2

Name the most common inhibitory NT in the CNS?

Answer 2

GABA

GAMMA - AMINOBUTYRIC ACID

Question 3

What happens without GABA?

Answer 3

NERVE CELLS CAN FIRE TOO OFTEN

Question 4

Name the anxiety impairments related to low GABA activity?

Answer 4

PANIC ATTACKS
\+
SEIZURE DISORDER
\+
COGNITIVE IMPAIRMENT

Question 5

Agonists such as Valium and Librium ___________ GABA activity.

Answer 5

INCREASE

Question 6

Do GABA supplements cross the BBB?

Answer 6

NO

placebo effect

Question 7

Caffeine ___________ GABA release

Answer 7

INHIBITS

Question 8

___________ is the most common excitatory neurotransmitter in the CNS.

Answer 8

GLUTAMATE

Question 9

Name the NT involved in most aspects of normal brain function; including cognition, memory and learning?

Answer 9

GLUTAMATE

Question 10

Too much glutamate is harmful, what if you have too little?

Answer 10

ALSO HARMFUL

Question 11

_____________ use glutamate to destroy infected neurons, virus and bacteria.
(this causes large amounts of collateral damage to healthy neurons)

Answer 11

MICROGLIA

Question 12

Name the self-perpetuating cycle where, due to chronic inflammation, microglia can become over-activated?

Answer 12

REACTIVE MICROGLIOSIS

Question 13

What is though to be the underlying mechanism of progressive neuron damage across numerous neurodegenerative diseases, regardless of instigating stimuli?

Answer 13

REACTIVE MICROGLIOSIS
(chronic inflammation = over-activated microglia)
(we CAN help inflammation!)