Flumazenil

Question 1

Flumazenil Trade Name?

Answer 1

Romazicon

Question 2

Flumazenil Classification?

Answer 2

Benzodiazepine Antagonist

Question 3

Flumazenil Mechanism?

Answer 3

Antagonizes the sedative effects of benzodiazepines in the CNS by inhibiting their actions on GABA

Question 4

Flumazenil Indications?

Answer 4

Respiratory depression and sedation associated with benzodiazepine overdose

Question 5

Flumazenil Contraindications?

Answer 5

-Hypersensitivity
-Tricyclic antidepressant overdose
-Seizure-prone patients
-Benzodiazepine dependence

Question 6

Flumazenil Side Effects/Precautions?

Answer 6

• Seizures
• Agitation
• Confusion
• Visual disturbances
• Headache
• Hypertension
• Nausea/vomiting
• Tachycardia

Question 7

Flumazenil Adult Dose?

Answer 7

Initial dose 0.2mg, increase by 0.1mg for effect up to 0.5mg/dose. Max 3mg total

Question 8

Flumazenil Pediatric Dose?

Answer 8

Not recommended

Question 9

Flumazenil Onset of Action?

Answer 9

1-2 minutes

Question 10

Flumazenil Duration of Action?

Answer 10

Variable: Related to benzodiazepine plasma concentration

Question 11

Flumazenil Max Dose Adult/Pediatric?

Answer 11

3mg

Question 12

Flumazenil Routes of Administration?

Answer 12

IV/IO

Question 13

Flumazenil How Supplied?

Answer 13

0.1mg/ml vials