Factors that Interfere with Wound Healing in Animals Flashcards
Factors that interfere with wound healing
physical
endogenous
exogenous categories
Ideal conditions to allow wound healing occur at ____°C.
30°C.
Decreasing the temperature to ____°C results in a 20% loss of tensile wound strength.
12°C
-Typically reflect the overall condition of the animal. Anemia may interfere with wound healing by creating low tissue oxygen levels.
- Nutrition
Endogenous factors
delays wound healing when the total serum protein content is <2 g/dL
hypoproteinemia
can alter the healing process.
malnutrition
(an important amino acid in wound repair)
DL-methionine or cysteine
can interfere with wound healing by slowing granulation tissue formation and inducing the synthesis of poor quality collagen
Uremia
contributes to poor wound healing through decreased blood supply and with poor suture holding in the subcutaneous fat layers.
Obesity
- include any external chemical that alters wound healing
Exogenous factors
is commonly implicated in wound complications.
Cortisone
` markedly inhibit capillary budding, fibroblast proliferation, and rate of epithelialization.
Corticosteroids
Similar to cortisone, ________ adversely affects wound healing by slowing collagen production. Vitamin C is required for hydroxylation of two amino acids, proline and lysine.
vitamin E
is required for epithelial and fibroblastic proliferation; however, excessive delays wound healing by inhibiting macrophage function
Zinc
Other factors that inhibit wound healing include radiation, alkylating agents (eg, cyclophosphamide, melphalan), and inappropriate concentrations of antiseptics.
