Example of Phase I and Phase 2

Question 1

What are the enxymes in phase I

Answer 1

Cytochrome P450s
Falvin-containing monooxygenases
Epoxide hydroxylases

Question 2

What are the enzymes in phase II

Answer 2

Sulfotransferases
UDP-glucuronosyltransferases
Glutathione-S-Transferases
N-acetyltransferases (NAT)
Methyltransferases (MT)

Question 3

What group of enzymes are in the “other group”

Answer 3

alcohol dehydrogenase
aldehyde dehydrogenase
NADPH-quinone oxidoreductase

Question 4

What is the name of phase I reactions?

Answer 4

Oxidation “oxygenases”

Question 5

What is the name of the phase II reactions?

Answer 5

Conjugation “Transferases”

Question 6

What does cytochrome P450 do?

Answer 6

Oxidation of : C and O

Dealkylation

Question 7

Flavin-Containing monoxygenases?

Answer 7

Oxidation: P,N,S

Question 8

Epoxide hydroxylases?

Answer 8

Hydrolysis of epoxides

Question 9

Sulfotransferases?

Answer 9

Addition of sulfate

Question 10

UDP-Glucuronosyltransferases

Answer 10

Addition of glucuronic acid

Question 11

Glutathione-S-Transferases

Answer 11

Addtion of glutathione

Question 12

N-Acetyltransferases?

Answer 12

addition of acetyl group

Question 13

Methyltransferases?

Answer 13

Addition of methyl group

Question 14

Alcohol dehydrogenases?

Answer 14

Reduction of alcohols

Question 15

Aldehyde Dehydrogenases?

Answer 15

Reduction of aldehydes

Question 16

NADPH-quinone oxidoreductases

Answer 16

Reduction of quinones