Exam Review/ Practice Questions Flashcards
True or False: In first order kinetic elimination, the drug half-life decreases with time.
False
True or False: Drugs slowly eliminated require more frequent dosing.
False
True or False: The smaller the volume of distribution (Vd), the greater the distribution of the drug outside the bloodstream.
False
True or False: Phase I metabolism of a drug always leads to its inactivation.
False
What is the main difference between passive and facilitated diffusion?
A.) Energy requirement
B.) Moving drugs against concentration gradient
C.) Involvement of carriers or channels
C.) Involvement of carriers or channels
Metabolism of drugs usually results in the:
A.) formation of metabolites which are usually more polar
B.) formation of metabolites which are less polar
C.) formation of substances which are more active than the drug itself
D.) liver toxicity
A.) formation of metabolites which are usually more polar
Which of the following is a correct statement regarding a partial agonist?
a.) It is a drug that is able to produce the full cell/tissue response
b.) It is a drug that induces a response, but the maximum response is less than the maximum response to a full agonist
c.) It is a drug that binds to the receptor, suppressing the receptor’s basal intrinsic activity
d.) It is a drug that has high affinity for the receptor, but has no intrinsic activity
b.) It is a drug that induces a response, but the maximum response is less than the maximum response to a full agonist
The first-pass effect is most apt to occur after which route of drug administration?
A.) Intravenous
B.) Intramuscular
C.) Subcutaneous
D.) Oral
E.) Inhalation
D.) Oral
True or False: The larger the TI the safer the drug.
True
A 20-kg dog is dosed with 5 mg of drug X. If the half-life of drug X is 30 minutes, how long will it take for the animal to have less than 1 mg of the drug remaining in the body?
A.) 90 minutes
B.) 120 minutes
C.) 150 minutes
D.) 210 minutes
A.) 90 minutes
The mechanism by which most drugs are absorbed following an intramuscular injection is
A.) passive diffusion
B.) active transport
C.) pinocytosis
D.) facilitated diffusion
A.) passive diffusion
All of the following are routes of excretion except?
a.) Kidney
b.) Lung
c.) Bile
d.) Fat
e.) Milk
d.) Fat
True or False: By passive reabsorption, it does not matter how lipid soluble a drug is.
False
True or False: Protein-bound drugs can be filtered by glomerulus.
False
Which of the following is a factor(s) affecting drug metabolism?
a.) species
b.) age
c.) diet and nutritional status
d.) health status/ diseases
e.) all of the above
e.) all of the above
Which of the following statements regarding phase I and II metabolic reactions is true?
a.) Phase II acts only on phase I metabolites
b.) Phase I acts on parent drugs and/or phase I metabolites
c.) Phase II acts on parent drugs and/or phase I metabolites
d.) Phase II only acts on parent drugs.
c.) Phase II acts on parent drugs and/or phase I metabolites
Which one of the following factors negatively affects the distribution of a drug?
a.) concentration gradient
b.) lipid solubility
c.) binding capacity
d.) nonionized status of drug
c.) binding capacity
Which one of the following parenteral route of administration is not recommended for large volumes of application?
a.) Intravenous (IV)
b.) Intraperitoneal (IP)
c.) Intramuscular (IM)
c.) Intramuscular (IM)
Which one of the following statements regarding weak acids and weak bases is correct?
a.) weak acids are better absorbed in alkaline conditions
b.) weak bases are better absorbed in acidic conditions
c.) weak acids are better absorbed in the small intestine
d.) weak bases are better absorbed in the stomach
e.) weak bases are better absorbed in alkaline conditions
e.) weak bases are better absorbed in alkaline conditions
