Exam Review

Question 1

Order the protein structures from least to most complex

Answer 1

Secondary -> Motif -> Domain -> Teritary

Question 2

Osteogenesis imperfecta results from a mutation in the gene encoding which protein?

Answer 2

Collagen

Question 3

Marfan’s Syndrome results from a mutation in the gene encoding which protein?

Answer 3

Fibrillin

Question 4

Williams Syndrome results from a mutation in the gene encoding which protein?

Answer 4

Elastin

Question 5

What could be a possible result of a H63G substitution in Hb?

Answer 5

Increase the affinity of CO binding heme

Question 6

T/F: Elastin contains hydroxylysine

Answer 6

FALSE

Question 7

Proteins that have quaternary structure most likely exhibit

Answer 7

Allosteric cooperativity

Question 8

T/F: At constant [enzyme], increasing the [substrate] leads to a proportional increase in the reaction rate

Answer 8

FALSE

Question 9

Which cyclic conformation is the least stable?

Answer 9

Half-chair

Question 10

What class of enzyme is PKA?

Answer 10

Transferase

Question 11

Where are non-polar R groups in aqueous solution located?

Answer 11

They are hydrophobic and found buried within proteins.

Question 12

What are immunoglobulin folds made up of?

Answer 12

A beta-barrel made by disulfide bonds

Question 13

What happens to the hydrogen that originates from the side chain of serine in the catalytic triad during the chymotrypsin mechanism?

Answer 13

Sequestered away by His64

Question 14

T/F: FR regions in antibodies have more stable amino acids compared to CDR regions

Answer 14

False

Question 15

T/F: Proline within the helix destabilizes the alpha helix

Answer 15

True

Question 16

Most molecular chaperones assist protein folding by

Answer 16

stabilizing the protein by binding hydrophobic residues

Question 17

What are epimers?

Answer 17

Monosaccharides that differ in configuration around one specific carbon atom

Question 18

Which phosphate of ATP is transferred to glucose during the first step of glycolysis?

Answer 18

Gamma phosphate

Question 19

His146R will lead to which of the following phenotypes?

Answer 19

Decreased affinity for oxygen, heterodimer interface altered to stabilize the T state, decreased cooperativity

Question 20

Inhibition of TMPRSS2 by camostat and nafamostat will result in which of the following?

Answer 20

Blocked fusion of the viral and host cell membranes

Question 21

Which peptide is most likely to form a covalently bonded dimer?

Answer 21

Look for any sequences that contain cysteine residue because cysteine is only AA that can form disulfide bonds

Question 22

Decreased Ca2+ availability will affect which protease the most?

Answer 22

Furin protease