Exam Review Flashcards
Order the protein structures from least to most complex
Secondary -> Motif -> Domain -> Teritary
Osteogenesis imperfecta results from a mutation in the gene encoding which protein?
Collagen
Marfan’s Syndrome results from a mutation in the gene encoding which protein?
Fibrillin
Williams Syndrome results from a mutation in the gene encoding which protein?
Elastin
What could be a possible result of a H63G substitution in Hb?
Increase the affinity of CO binding heme
T/F: Elastin contains hydroxylysine
FALSE
Proteins that have quaternary structure most likely exhibit
Allosteric cooperativity
T/F: At constant [enzyme], increasing the [substrate] leads to a proportional increase in the reaction rate
FALSE
Which cyclic conformation is the least stable?
Half-chair
What class of enzyme is PKA?
Transferase
Where are non-polar R groups in aqueous solution located?
They are hydrophobic and found buried within proteins.
What are immunoglobulin folds made up of?
A beta-barrel made by disulfide bonds
What happens to the hydrogen that originates from the side chain of serine in the catalytic triad during the chymotrypsin mechanism?
Sequestered away by His64
T/F: FR regions in antibodies have more stable amino acids compared to CDR regions
False
T/F: Proline within the helix destabilizes the alpha helix
True
Most molecular chaperones assist protein folding by
stabilizing the protein by binding hydrophobic residues
What are epimers?
Monosaccharides that differ in configuration around one specific carbon atom
Which phosphate of ATP is transferred to glucose during the first step of glycolysis?
Gamma phosphate
His146R will lead to which of the following phenotypes?
Decreased affinity for oxygen, heterodimer interface altered to stabilize the T state, decreased cooperativity
Inhibition of TMPRSS2 by camostat and nafamostat will result in which of the following?
Blocked fusion of the viral and host cell membranes
Which peptide is most likely to form a covalently bonded dimer?
Look for any sequences that contain cysteine residue because cysteine is only AA that can form disulfide bonds
Decreased Ca2+ availability will affect which protease the most?
Furin protease
