Exam

Question 1

Checkpoint Inhibitors’ may be useful for the management of neoplasia by blocking which of the following tumour survival mechanisms?
A. Down regulation of HLA expression
B. Down regulation of the inhibitory molecule PD-L1
C. Up regulation of the inhibitory molecule PD-1
D. Up regulation of the inhibitory molecule PD-L1

Answer 1

D. Up regulation of the inhibitory molecule PD-L1

Question 2

Peutz Jegher Syndrome

Answer 2

• Peutz-Jeghers syndrome (PJS) is a rare inherited disease that is characterised by gastrointestinal polyps in association with pigmentation affecting skin and mucous membranes.
• PJS polyps are hamartomas i.e. benign tumours made up of a mixture of mature cells normally found in that tissue. They can show benign (non-cancerous) or malignant (cancerous) changes. The risk of developing some form of internal cancer is 15 times greater for patients with PJS compared with the general population.
• STK11 gene
• Autosomal dominant