Exam 1 Zhang Flashcards
1
Q
Why can’t dopamine itself be used to treat PD?
A
Dopamine can’t pass the BBB
2
Q
How does tolcapone work?
A
It’s a catechol-O-methyltransferase (COMT) inhibitor
3
Q
What does COMT do?
A
Breaks down Ldopa in the periphery to OMD. Also breaks down Dopamine in the brain to 3 MT. We don’t want these things to happen. We want most of Ldopa to get into the brain. And we want dopamine to stay dopamine in the brain
4
Q
What is the primary receptor that’s affected by PD drugs
A
D2 Receptor
5
Q
How does memantine work?
A
It’s an antagonist at the NMDA receptor.
6
Q
What is the brand of memantine?
A
Namenda
7
Q
What does the NMDA receptor do in dementia?
A
.
8
Q
Meds to treat PD (6)
A
Ldopa/cdopa COMT inhibitor MOA-B inhibitor Dopamine agonist NMDA receptor antagonist anticholinergics
