Eurkaryotic Cell Cycle Flashcards

1
Q

The enzymes and proteins necessary for cell division are

synthesized in which phase

A

G2

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2
Q

A mutation in Cyclin E that interferes with its binding
to Cdk2 would prevent which of the following
processes?

A

Passage from G1 to S

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3
Q

The DNA checkpoint kinases, Chk1 and Chk2, phosphorylate Cdc25
resulting in its inhibition. Cdc25 is required for the activation of
both Cdk1 and Cdk2. Inhibition of Cdk1 would lead to?

A

G2 phase arrest

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4
Q

What effect would a mutant of Rb that can no longer be phosphorylated by
Cdk4/Cdk6 have on progression through the cell cycle?

A

Transcription of genes necessary for cell cycle progression would be
repressed

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5
Q

Growth factors induce the synthesis of

A

Cyclin D

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