ETC/Oxidative Phosphorylation Flashcards
Where does the electron transport chain occur?
Inner mitochondrial membrane
Where does Glycolysis occur? PDH Complex? Citric Acid Cycle? ETC?
- Glycolysis: cytosol
- PDH Complex: mitochondria
- Citric Acid Cycle: mitochondrial matrix
- ETC: inner mitochondrial membrane
Which enzyme functions in BOTH the citric acid cycle and the electron transport chain (ETC)?
Succinate dehydrogenase (SDH)
For the ETC, which molecule is the final electron acceptor?
Oxygen
In the ETC the net yield of ATP per glucose varies. This range exists because cytosolic NADH formed through glycolysis cannot directly cross into the mitochondrial matrix, therefore NADH shuttles are required. What are these two shuttles?
- G3P shuttle
- malate–aspartate shuttle
Which complex of the ETC is linked with the citric acid cycle?
Complex II
(Complex II does NOT pump protons into the intermembrane space.)
Which three complexes of the ETC pumps protons into the intermembrane space?
- Complex I
- Complex III
- Complex IV
[Mnemonic]
FADH2 is fed into Complex 2.
(how to remember which complex of the ETC that FADH2 transfers its electrons to)
FADH2 is fed into Complex 2.
FADH2 transfers its electrons into Complex II of the ETC.
What is the process of chemiosmotic coupling that occurs during oxidative phosphorylation?
Describes a direct relationship between the proton gradient and ATP synthesis.
What is the process of oxidative phosphorylation?
ATP is generated via ATP synthase using the proton gradient from the ETC.
If complex I of the ETC were inhibited, would that have any effect on ATP generated by FADH2? Why?
NO
Because FADH2 feeds into Complex II first and NOT Complex I, so any inhibition on Complex I has no effect on Complex II.
Which enzyme harvests the energy of the proton gradient in the ETC to make ATP?
ATP synthase
Does the electron transport chain occur aerobically or anaerobically?
Aerobically
