esophageal CA staging Flashcards
esoph CA
Tis
depth of invasion
confined to epithelium
i.e. NOT invading the basement membrane
= definition of high-grade dysplasia (HGD)
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T1a
depth of invasion
mucosa:
lamina propria OR muscularis mucosae
into but not through
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T1b
depth of invasion
submucosa
into but not through
broken down into SM1/2/3 for superfic/middle/deep 1/3 of submucosa respectively
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T2
depth of invasion
muscularis propria
into but not through
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T3
depth of invasion
adventitia
i.e. has escaped the esophagus
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T4
depth of invasion
adjacent structures
subcategorized into T4a & T4b by resectability
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T4a
depth of invasion
resectable structures:
pleura
pericardium
azygos vein
diaphragm
peritoneum
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T4b
depth of invasion
unresectable structures
all else from T4a incl:
aorta
vertebral body
trachea
adjacent visceral organs (incl liver, pancreas, lung, spleen)
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
layers of the esophageal wall
starting from internal lumen moving externally
for staging;
- epithelium (mucosa)
- basement membrane (mucosa)
- lamina propria (mucosa)
- muscularis mucosae (mucosa)
- submucosa
- muscularis propria (incl circular & longitudinal fiber layers)
- [adventitia]
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
N0
self-explanatory
esoph CA
N1
1-2 regional LN+
any regional LN
esoph CA
N2
3-6 regional LN+
any regional LN
esoph CA
N3
7+ regional LN+
any regional LN
esoph CA
M0
self-explanatory
esoph CA
M1
any distant met(s)
Does adenoCA staging, SCC staging, or both incorporate location of the tumor?
SCC only
(L-upper/middle/lower)
esoph CA
L-upper (for SCC)
cervical esophagus to lower border of azygos vein
esoph CA
L-middle (for SCC)
lower border of azygos vein to lower border of IPV
IPV = inferior pulmonary vein
esoph CA
L-lower (for SCC)
lower border of IPV to stomach, incl GEJ
IPV = inferior pulmonary vein
esoph CA
How is location defined for L-category (for SCC)?
(or for Siewert classification of GEJ CA)
by “epicenter”
EGD distance (from incisors) of:
UES
15cm
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
EGD distance (from incisors) of:
sternal notch
20cm
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
EGD distance (from incisors) of:
azygos vein
25cm
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
EGD distance (from incisors) of:
IPV
30cm
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
EGD distance (from incisors) of:
LES
40cm
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
EGD distance (from incisors) of:
GEJ
40-42cm
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
Siewert I
definition
5cm prox to GEJ
to 1cm prox to GEJ
GEJ defined as Z-line
https://drive.google.com/file/d/197a9Fj0M2bSiCo0Fh4YgqYx7tK1bEgfg/view
Siewert II
definition
1cm prox to GEJ
to 2cm dist to GEJ
GEJ defined as Z-line
https://drive.google.com/file/d/197a9Fj0M2bSiCo0Fh4YgqYx7tK1bEgfg/view
Siewert III
definition
2cm dist to GEJ
to 5cm dist to GEJ
tx as gastric CA
GEJ defined as Z-line
https://drive.google.com/file/d/197a9Fj0M2bSiCo0Fh4YgqYx7tK1bEgfg/view
cervical esophagus
distance/definition
15-20cmFI
UES : sternal notch
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view?usp=drive_fs
upper [thoracic] esophagus
distance/definition
20-25cmFI
sternal notch : azygos vein
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view?usp=drive_fs
middle [thoracic] esophagus
distance/definition
25-30cmFI
azygos vein : IPV
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view?usp=drive_fs
distal [thoracic] esophagus
distance/definition
30-40cmFI
IPV : LES
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view?usp=drive_fs
esoph CA
SCC cI
T1 N0-1
esoph CA
adenoCA cI
T1 N0 only
esoph CA
difference between SCC & adenoCA cI
both include T1 N0
only SCC also incl T1 N1
esoph CA
SCC cII
T2 N0-1
T3 N0
esoph CA
Are there substages of SCC cII?
NO
esoph CA
Are there substages of adenoCA cII?
YES
esoph CA
Are there substages of cIII for either adenoCA or SCC?
NO
esoph CA
adenoCA cIIA
T1 N1 only
esoph CA
adenoCA cIIB
T2 N0 only
note that T2 is worse than N1
esoph CA
adenoCA cIII
T3-4a N0
T2-4a N1
esoph CA
adenoCA cIVA
T4b
N2
N3
esoph CA
SCC cIII
T3 N1
T1-3 N2
esoph CA
SCC cIVA
T4a-T4b
N3
esoph CA
cIVB (either SCC or adenoCA)
M1
How is tumor grade used in esophageal CA p-staging?
substratifies T stage for T1a,T1b,T2 in adenoCA & for T1a,T2,T3 in SCC
esoph CA
T-stage: confined to the epithelium
i.e. NOT through the basement membrane
Tis
= definition of high-grade dysplasia
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades lamina propria
into but not through
T1a
confined to the mucosa
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades muscularis mucosae
into but not through
T1a
confined to the mucosa
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades submucosa
into but not through
T1b
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades muscularis propria
into but not through
T2
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades adventitia
i.e. has escaped the esophagus
T3
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades adjacent structures
T4
subcategorized into T4a & T4b by resectability
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades pleura
T4a
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades pericardium
T4a
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades azygos vein
T4a
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades diaphragm
T4a
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades peritoneum
T4a
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades aorta
T4b
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades vertebral body
T4b
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
T-stage: invades trachea
T4b
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
What layers of the esophageal wall comprise the mucosa?
in order from luminal outward
layers of the esophageal wall
(starting from internal lumen moving externally)
1. epithelium
2. basement membrane
3. lamina propria
4. muscularis mucosae
5. submucosa
6. muscularis propria (incl circular & longitudinal fiber layers)
7. [adventitia]
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
What are the primary (big picture) layers of the esophageal wall?
in order from luminal outward
1. mucosa
2. submucosa
3. muscularis
layers of the esophageal wall
(starting from internal lumen moving externally)
1. epithelium
2. basement membrane
3. lamina propria
4. muscularis mucosae
5. submucosa
6. muscularis propria (incl circular & longitudinal fiber layers)
7. [adventitia]
https://drive.google.com/file/d/1HC1jAdUxITpbG7PY_yVDqhRF47PcnnvF/view
esoph CA
N-stage: 1-2 LN+
any regional LN
N1
esoph CA
N-stage: 3-6 LN+
any regional LN
N2
esoph CA
N-stage: 7+ LN+
any regional LN
N3
esoph CA
L-stage: cervical esophagus to lower border of azygos vein
L-upper (for SCC)
esoph CA
L-stage: lower border of azygos vein to lower border of IPV
IPV = inferior pulmonary vein
L-middle (for SCC)
esoph CA
L-stage: lower border of IPV to stomach, incl GEJ
IPV = inferior pulmonary vein
L-lower (for SCC)
Siewert class:
5cm prox to GEJ
to 1cm prox to GEJ
GEJ defined as Z-line
https://drive.google.com/file/d/197a9Fj0M2bSiCo0Fh4YgqYx7tK1bEgfg/view
Siewert I
Siewert class:
1cm prox to GEJ
to 2cm dist to GEJ
GEJ defined as Z-line
https://drive.google.com/file/d/197a9Fj0M2bSiCo0Fh4YgqYx7tK1bEgfg/view
Siewert II
Siewert class:
2cm dist to GEJ
to 5cm dist to GEJ
GEJ defined as Z-line
https://drive.google.com/file/d/197a9Fj0M2bSiCo0Fh4YgqYx7tK1bEgfg/view
Siewert III
tx as gastric CA
15-20cmFI
region
cervical esophagus
= UES : sternal notch
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view?usp=drive_fs
UES : sternal notch
region
cervical esophagus
= 15-20cmFI
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view?usp=drive_fs
20-25cmFI
region
upper [thoracic] esophagus
= 20-25cmFI
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view?usp=drive_fs
sternal notch : azygos vein
region
upper [thoracic] esophagus
= sternal notch : azygos vein
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view?usp=drive_fs
azygos vein : IPV
region
middle [thoracic] esophagus
= 25-30cmFI
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view?usp=drive_fs
25-30cmFI
region
middle [thoracic] esophagus
= azygos vein : IPV
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view?usp=drive_fs
IPV : LES
region
distal [thoracic] esophagus
= 30-40cmFI
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view?usp=drive_fs
30-40cmFI
region
distal [thoracic] esophagus
= IPV : LES
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view?usp=drive_fs
esoph CA
SCC c-stage: T1 N0-1
SCC cI
esoph CA
SCC c-stage: T1 N0
SCC cI
esoph CA
SCC c-stage: T1 N1
SCC cI
esoph CA
SCC c-stage: T2-3 N0
SCC cII
esoph CA
SCC c-stage: T2 N1
SCC cII
esoph CA
SCC c-stage: T2 N0
SCC cII
esoph CA
SCC c-stage: T3 N0
SCC cII
esoph CA
adenoCA c-stage: T1 N0
adenoCA cI
(T1 N0 is the only cI)
esoph CA
adenoCA c-stage: T1 N1
adenoCA cIIA
(T1 N1 is the only cIIA)
note that N1 is not as bad as T2
esoph CA
adenoCA c-stage: T2 N0
adenoCA cIIB
(T2 N0 is the only cIIB)
note that T2 is worse than N1
esoph CA
adenoCA c-stage:
T3-4a N0
adenoCA cIII
esoph CA
adenoCA c-stage:
T3 N0
adenoCA cIII
esoph CA
adenoCA c-stage:
T4a N0
adenoCA cIII
esoph CA
adenoCA c-stage:
T2-4a N1
adenoCA cIII
esoph CA
adenoCA c-stage:
T2 N1
adenoCA cIII
esoph CA
adenoCA c-stage:
T3 N1
adenoCA cIII
esoph CA
adenoCA c-stage:
T4a N1
adenoCA cIII
esoph CA
adenoCA c-stage: T3-4a N0
adenoCA cIII
esoph CA
adenoCA c-stage: T3 N0
adenoCA cIII
esoph CA
adenoCA c-stage: T4a N0
adenoCA cIII
esoph CA
adenoCA c-stage:
T2-4a N1
adenoCA cIII
esoph CA
minimum adenoCA c-stage: T4b
adenoCA cIVA
esoph CA
adenoCA c-stage: N2
adenoCA cIVA
esoph CA
adenoCA c-stage: N3
adenoCA cIVA
esoph CA
adenoCA c-stage: M1
cIVB (either SCC or adenoCA)
esoph CA
SCC c-stage: T3 N1-2
SCC cIII
esoph CA
SCC c-stage: T1-2 N2
SCC cIII
esoph CA
SCC c-stage: T4a-T4b N3
SCC cIVA
esoph CA
SCC c-stage: M1
cIVB (either SCC or adenoCA)
landmark @ 15cm
EGD distance (from incisors)
UES
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
landmark @ 20cm
EGD distance (from incisors)
sternal notch
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
landmark @ 25cm
EGD distance (from incisors)
azygos vein
also probably carina
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
SEER: 23-24cm https://training.seer.cancer.gov/ugi/anatomy/esophagus.html
by EUS: 25.7cm on average https://pubmed.ncbi.nlm.nih.gov/14570085/
landmark @ 25cm
EGD distance (from incisors)
carina (23-26cm)
also azygos vein
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
SEER: 23-24cm https://training.seer.cancer.gov/ugi/anatomy/esophagus.html
by EUS: 25.7cm on average https://pubmed.ncbi.nlm.nih.gov/14570085/
landmark @ 30cm
EGD distance (from incisors)
IPV
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
landmark @ 40cm
EGD distance (from incisors)
LES
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
landmark @ 40-42cm
EGD distance (from incisors)
GEJ
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
esoph CA
minimum adenoCA c-stage: T2
adenoCA cIIB
esoph CA
minimum adenoCA c-stage: T3
adenoCA cIII
esoph CA
minimum adenoCA c-stage: N1
adenoCA cIIA
esoph CA
minimum adenoCA c-stage: N2
adenoCA cIVA
esoph CA
minimum adenoCA c-stage: T4b
adenoCA cIVA
esoph CA
adenoCA I v II
differentiating stage criteria
T2 OR N1
T2 (N0) = IIB; (T1) N1 = IIA
esoph CA
adenoCA IIA v IIB
differentiating stage criteria
N1 (IIA) v T2 (IIB)
(T1) N1 = IIA; T2 (N0) = IIB
esoph CA
adenoCA IVA v IVB
differentiating stage criteria
M1 = IVB
same in SCC
esoph CA
SCC IVA v IVB
differentiating stage criteria
M1 = IVB
same in adenoCA
esoph CA
adenoCA II v III
differentiating stage criteria
T2 N0 OR T1 N1 v
T3 (N0) OR (T2-4a) N1
esoph CA
adenoCA III v IVA
differentiating stage criteria
T4b OR N2+
esoph CA
SCC III v IVA
differentiating stage criteria
T4a+ OR N3
esoph CA
SCC I v II
differentiating stage criteria
T2-3 OR N1
T2-3 N0 & T2 N1
esoph CA
SCC c-stage: T1 N1
cI
only N+ stage I
esoph CA
SCC IIA v IIB
differentiating stage criteria
trick Q: NO substages
for SCC II; only SCC substages are for IV: IVA/IVB
esoph CA
SCC II v III
differentiating stage criteria
T3 N1 OR <T4 N2
i.e. T3 N1 & T1-3 N2
esoph CA
minimum adenoCA c-stage: T4a
adenoCA cIII
esoph CA
minimum SCC c-stage: T4a
SCC cIVA
esoph CA
minimum SCC c-stage: T2
SCC cII
esoph CA
minimum SCC c-stage: T3
SCC cII
esoph CA
minimum SCC c-stage: N1
SCC cI
esoph CA
minimum SCC c-stage: N2
SCC cIII
esoph CA
minimum SCC c-stage: N3
SCC cIVA
esoph CA
minimum adenoCA c-stage: N3
adenoCA cIVA
esoph CA
adenoCA c-stage: Tis
adenoCA c0
esoph CA
SCC c-stage: Tis
SCC c0
esoph CA
risk of +N with T1a
<3%
esoph CA
risk of +N with T1b
25%
esoph CA
risk of +N with T2
25-50%
esoph CA
risk of +N with T3
75-80%
esoph CA
indication for bronchoscopy as part of staging w/u (at time of esophagectomy)
+resp sx
upper & mid-esophageal (@ or above carina)
esp SCC
EGD distance (from incisors) of:
carina
25cm (~23-26cm)
https://drive.google.com/file/d/1HM9tm22JDxHLW5iGeVQm7r9SXZa_wyuT/view
SEER: 23-24cm https://training.seer.cancer.gov/ugi/anatomy/esophagus.html
by EUS: 25.7cm on average https://pubmed.ncbi.nlm.nih.gov/14570085/
NCCN recommended w/u for esophageal CA
EGD + bx
CT C/A/P with PO+IV contrast
PET-CT
Siewert classification
EUS ± EMR for staging T1a/T1b
± bronch if tumor @ or above carina
± lap staging/peritoneal washing for Siewert II
NCCN recommended pathologic testing during w/u of esophageal CA
MSI testing by NGS or MMR IHC
PD-L1 testing for advanced
Her2 for metastatic adenoCA
Do celiac axis nodes count as regional (i.e. non-metastatic) dz for esophageal CA?
YES
What are the regional (versus distant=metastatic) LN for esophageal CA?
all para/periesophageal LN from neck to celiac axis, incl:
paratracheal (cervical & thoracic)
level 7
9R/9L
L gastric
prox common hepatic artery
prox splenic artery
celiac artery down to base
(but NOT incl supraclav LN, which are not considered peri/para)
EUS appearance of LN suspicious for esophageal CA involvement
enlarged, hypoechoic (dark), homogeneous, well-circumscribed, rounded structures
(confirm with FNA)
indication(s) to consider laparoscopic staging incl peritoneal washing/cytology
cT3 or cN+
How is ⊕peritoneal washing/cytology considered for esophageal CA staging?
M1
minimum # LN required for adequate oncologic resxn/staging of esophageal CA if NO induction chemoRT/neoadjuvant
15 LNs
minimum # LN required for adequate oncologic resxn/staging of esophageal CA AFTER induction chemoRT/neoadjuvant
15 LNs
(actually unknown, but recommendation the same)
procedure of peritoneal washing during staging laparoscopy for esophageal/GEJ CA without e/o macroscopic peritoneal dz
200mL saline @ RUQ, LUQ, pelvis (each), collected in Lukens trap
(UpToDate)