Erectile Dysfunction (Final Exam)

Question 1

this is the inability to achieve sustained erection in order to satisfactory perform sexual acts

Answer 1

erectile dysfunction (ED)

Question 2

what are the two classes of drugs used to treat ED

Answer 2

1. phosphodiesterase-5 inihbitors (PDE5i)
2. Prostaglandin E1 analogs (Caverject)

Question 3

what is the MOA of PDE5 inhibitors (e.g. sildenafil, vardenafil, tadalafil)?

Answer 3

inhibition of PDE5 located in penile vascular smooth muscle cells. cGMP levels are increased by delaying the degradation, which promotes smooth muscle relaxation in response to sexual stimulation

Question 4

which PDE5i is used daily

Answer 4

tadalafil (Cialis)

Question 5

what are some drug interactions with PDE5i?

Answer 5

nitrates! anti-hypertensives! <- these can make blood pressure bottom out
+ metabolized by CYP3A4 therefore watch for strong inhibitors

Question 6

what are some s/e of PDE5i?

Answer 6

headache, flushing, dyspepsia, nasal stuffiness
VIAGRA = BLUE VISION (REVERSIBLE) THINK BLUE BOX