epilepsy drugs Flashcards
hepatic enzyme inducers
carbamazepiene phenytoin phenobarbitol primidone topiramate oxcarbazepine
what should you offer a women with epilepsy when considering contraception
the IUD is likely best bet
- cocp efficacy is affected
- progestrerone only pill should be avoided
- depo injection requires a top up
does the morning after pill work if taking a hepatic enzyme inducer
no
- consider offering the IUD
what things are important to ask about in an epilepsy review
driving occupation swimming considering pregnancy precipitants any aura??? sign of a partial seizure - will affect driving
if considering pregnancy what - other than swapping medications - should you advise the patient to take
vit k and folic acid
everyone should also be offered vitamin D
which drugs act on presynaptic voltage gated channels?
carbamazepiene
lamotrigine
phenytoin
and others
what is the main chemical imbalance in epilepsy
GABA
retigabin MOA
acts of presynaptic voltage-gated K channels
what is required for NT release from the presynaptic cleft
SV2A
MOA of pregabalin, gabapentin and ethosuximide
acts of presynaptic voltage=gated ca channels
which medication (used in generalised seizurs) enhances GABA release from the pre-synaptic terminal?
NA val
BZPs, barbiturates, felbamate and topiramate have what MOA?
target the GABAa receptor to reduce excitability
side effects of NA val
weight gain
teratogenic
hair loss
fatigue
which medication can make generalised seizures worse?
carbamazepine
side effects of topiramate
sedation, weight loss and dysphasia
