Enterics/Anaerobes II Flashcards
Dysentery + fever
EIEC
Rearranges cytoskeleton (actin) to move
EIEC
Intracellular infection –> loss of nml cell signaling transduction
EPEC
Watery +/- bloody diarrhea, no fever
EPEC
incr osteomyelitis risk w/ SCD
Salmonella enteritidis + S. typhimuium
Migrates ro RES
Salmonella typhi
May cause Reiter’s
Yersinia enterocolitica
Humans = only reservoir
EIEC, Shigella
2 types of type III (inj into M cells + macrophages)
Salmonella typhi
Perforation of GIT at necrotic peyer’s patches –> hemorrhage
Salmonella typhi
Sudden-onset of abd cramps, watery diarrhea –> bloody diarrhea in 24h (+/- fever)
EHEC
Fecal leukocytes
Shigella
LEE from PAI mediates attachment and effacement
EHEC, EPEC
3rd world inf
EIEC
Secretes LT (binds GM1 gangliosides, ADP ribosylase) + ST (binds guanylyl cyclase receptor)
ETEC
Loss of microvilli –> osmotic diarrhea
EPEC
Localized inf of macrophages in lamina propria -> gastroenteritis
Salmonella enteritidis + S. typhimuium
Non-motile E. coli
EIEC
meat, dairy, poultry, reptiles, turtles
Salmonella enteritidis + S. typhimuium
Abx contraindicated due to lysogenic phase
EHEC
Contaminated food/water –> watery diarrhea
ETEC
Enter gut M cell –> escape phagocytic vesicle –> affects neighboring enterocytes
Shigella
colonizes SI via fimbriae
ETEC
Tir secreted to bridge intimin w/ enterocyte
EHEC
K-antigen –> neonatal meningitis
UPEC
phage encoded cytotoxin cleaves 28S RNA of ribosome
EHEC, Shigella