Enterics/Anaerobes II Flashcards
Dysentery + fever
EIEC
Rearranges cytoskeleton (actin) to move
EIEC
Intracellular infection –> loss of nml cell signaling transduction
EPEC
Watery +/- bloody diarrhea, no fever
EPEC
incr osteomyelitis risk w/ SCD
Salmonella enteritidis + S. typhimuium
Migrates ro RES
Salmonella typhi
May cause Reiter’s
Yersinia enterocolitica
Humans = only reservoir
EIEC, Shigella
2 types of type III (inj into M cells + macrophages)
Salmonella typhi
Perforation of GIT at necrotic peyer’s patches –> hemorrhage
Salmonella typhi
Sudden-onset of abd cramps, watery diarrhea –> bloody diarrhea in 24h (+/- fever)
EHEC
Fecal leukocytes
Shigella
LEE from PAI mediates attachment and effacement
EHEC, EPEC
3rd world inf
EIEC
Secretes LT (binds GM1 gangliosides, ADP ribosylase) + ST (binds guanylyl cyclase receptor)
ETEC
Loss of microvilli –> osmotic diarrhea
EPEC
Localized inf of macrophages in lamina propria -> gastroenteritis
Salmonella enteritidis + S. typhimuium
Non-motile E. coli
EIEC
meat, dairy, poultry, reptiles, turtles
Salmonella enteritidis + S. typhimuium
Abx contraindicated due to lysogenic phase
EHEC
Contaminated food/water –> watery diarrhea
ETEC
Enter gut M cell –> escape phagocytic vesicle –> affects neighboring enterocytes
Shigella
colonizes SI via fimbriae
ETEC
Tir secreted to bridge intimin w/ enterocyte
EHEC
K-antigen –> neonatal meningitis
UPEC
phage encoded cytotoxin cleaves 28S RNA of ribosome
EHEC, Shigella
O1H57
EHEC
Large invasion plasmid (can get into lamina propria)
Shigella
Does not decarboxylate lysine
EIEC
Shiga toxin
EHEC, Shigella
incr bacteremia risk w/ AIDS + Hodgkins
Salmonella enteritidis + S. typhimuium
MDR
S. dysenteriae
Vi capsule inh neutrophil uptake
Salmonella typhi
Produces more Shigella toxin than others
S. dysenteriae
Multiplies w.in epithelial cells of colon
EIEC
MC cause of Shigellosis in US
S. sonnei
Opportunistic cause of meningitis in neonates, brain abscesses, endocarditis
Citrobacter
eggs
Salmonella enteritidis
P fimbrae
UPEC
Moderately invasive + inflammatory response
EPEC
Live attenuated oral vaccine
Salmonella typhi
MC cause of AKI in peds patients
EHEC
Sorbitol negative
EHEC
Pseudoappendicitis
Yersinia enterocolitica
Non motile glu fermenter
Shigella
NV, abd cramps 20-72h after eating
Salmonella enteritidis + S. typhimuium
Watery diarrhea + abd pain –> scant bloody diarrhea + mucus/pus + cramps + tenesmus
Shigella
Microthrombi –> HUS (anemia, acute renal failure)
EHEC, Shigella
Insidious rising fever, HA, abd pain, conf, rosette spots
Salmonella typhi
MC in gay men
S. flexneri
Invades/destroys colonic tissue
EIEC
Siderophores
UPEC
PAI type III secretion (M cells)
Salmonella enteritidis + S. typhimuium
Leading cause of infantile diarrhea (3rd world)
EPEC
Hemolysin (= forms pores)
UPEC
Glu fermenter w/ gas + H2S
Salmonella enteritidis + S. typhimuium
Cattle, bad milk, contaminated water, daycares
EHEC
Enterocolitis, fever, diarrhea, abd pain (mesenteric lymphadenitis)
Yersinia enterocolitica
MC in old/young
Salmonella enteritidis + S. typhimuium
Indian subcontinent
S. boydii
S + Central Am
S. dysenteriae
aggressive abx (ceftriaxone)
Salmonella typhi
Pigs + pets
Yersinia enterocolitica
Non-lac fermenting E. coli
EIEC
MC cause of Traveler’s diarrhea + other causes
ETEC (MC), EIEC
Glu fermentation w/o gas, H2S
Salmonella typhi
EAF mediates localized binding
EPEC