Embryonal Cancer Genes Flashcards
1
Q
What cells do the majority of adult cancers arise from
A
90% from epithelial cells
2
Q
What translocations occur in the Ewings and PNET Tumorus
A
Get a EWS-FL1 fusion protein formed due to a Chr (22:11 translocation)
Can also get it fusion with ETC1 and ERG gene
3
Q
What translocation occurs in desmosplastic small round cell tumour
A
t(11:22) produces EWS-Wt1 fusion protein
Wt1 is a Zn finger gene with 4 zn fingers in its binding domain, only 3 involved in fusion
4
Q
Translocation in ARMS
A
t(1;13)
t(2:13)
5
Q
How many exons is the Rb gene
A
27 exons - TTSG codes for a 110kDa proteint hat is involved in the cell cycle
