Drugs for bad bugs Flashcards by emily chetwin | Brainscape

Q

Define bacteriostatic

A

Agent prevents growth of bacteria

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Q

Define bactericidal

A

Agent kills bacteria

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Q

Factors limiting drug efficacy

A

genetic drug resistance
phenotypic drug tolerance
intrinsic drug resistance

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Q

Factors influencing intrinsic drug resistance

A

permeability
efflux
enzymatic modification/ degradation

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Q

Factors influencing genetic drug resistance

A

resistance elements

- mutations

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Q

How is genetic resistance acquired?

A

HGT

- de novo mutation

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Q

Describe resistance in Mtb

A

driven by chromosomal rearrangements and point mutations

- no evidence of HGT or plasmids

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Q

First line treamtent for Mtb

A

2 months

Isoniazid
Rif
Ethambutol
Pyrazinamide
Streptomycin

4 months

Isoniazid
Rif

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Q

Name an emerging drug-resistant Mtb strain in WC

A

DRF150

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Q

How to measure fitness

A

growth in vitro
competition in vitro
competition in vivo

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