Drugs and the endocrine system

Question 1

Mineralglucocorticoids

Answer 1

Fludrocortione - treats adrenal insufficiency

Question 2

Glucocorticoids

Answer 2

Hydrocortisone - addisons disease/crisis. Adrenal insufficiency or reduce inflammaton.
Used topically for eczema

Prenilasone - taken orally. asthma attack (acute)

Methprednisolone (used for transplant rejection.

Dexamethasone - high anti inflammatory action. Treats cerebal oedemas.

Beclamethasone - asthma inhaler

Question 3

Unwanted effects of glucocorticoids

Answer 3

Hump, stunted growth, muscle wasting, moon face, hypertension, osteoperosis, increased abdominal fat.

inhaled glucocortisoids - hoarseness/thrush

Withdrawal - gradual or can send someone into addisonian crisis.

Question 4

Thyroid disease

Answer 4

Goitre - underactive thyroid T3/T4 - insufficient iodine.
Disruption to negative feedback.

Treatment - Thyroxine substitute. Levothyroxine T4
Triodothyronine T3

Lithium

Can result in hypocalcaemia - inadequate ca2 intake. Lack of vit D.

Treatment - calcium cromcororate IV infusion or ergocalciferol (VIT D) or calcitriol.

Question 5

Hyperthyroidism

Answer 5

Graves disease autoimmune condition. Patients undergo remission. Treatment does not cure the problem.

Carbimazole limits the synthesis of thyroxine. absorbed in gut and converted in liver to active form (pro drug). Excreted in Urine.
Side effect - nausea, vomiting, sore throat, insomnia, mouth ulcers.