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PT2 Neuro 1-5 > Drugs > Flashcards

Drugs Flashcards

1
Q

phenytoin MOA

A
  • blocks high frequency voltage gated Na-channels

- antagonizes NMDA

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2
Q

carbamazepine MoA

A

-blocks high frequency voltage gated Na-channels

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3
Q

phenytoin adverse reactions

A
  • gingival hyperplasia
  • osteoporosis
  • dyskinesias
  • hepatic failure
  • cognitive impairment
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4
Q

oxcarbazepine MoA

A

-blocks high frequency voltage gated Na-channels

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5
Q

gabapentin MoA

A
  • Ca channel blocker

- suppress NMDA receptor

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6
Q

carbamazepine adverse reactions

A
  • blurry vision
  • rash
  • osteoporosis
  • sexual dysfunction
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7
Q

levetiracetam MoA

A

-modulates kainate receptor (glutamate)

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8
Q

pregabalin MoA

A
  • increase glutamic acid decarboxylase

- suppresses Ca current

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9
Q

valproate adverse reactions

A
  • weight gain
  • tremor
  • behavioral changes
  • PCOS
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10
Q

phenobarbital MoA

A

-prolong GABA channel opening

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11
Q

diazepam MoA

A

-increase frequency of GABA channel opening

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12
Q

ethosuximide adverse reactions

A
  • nausea
  • fatigue
  • headache
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13
Q

lamotrigine MoA

A
  • blocks high frequency voltage gated Na-channels
  • blocks kainate receptors
  • H-current enhancement
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14
Q

lacosamide MoA

A

-enhances slow inactivation of voltage gated Na channels

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15
Q

gabapentin adverse reactions

A
  • weight gain
  • somnolence
  • dizziness
  • fatigue
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16
Q

tiagabine MoA

A

-interferes with GABA reuptake

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17
Q

zonisamide MoA

A
  • blocks high frequency voltage gated Na-channels

- Ca channel blocker

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18
Q

lamotrigine adverse reactions

A
  • rash
  • dizziness
  • blurred vision
  • headache
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19
Q

lacosamide adverse reactions

A

dizziness
somnolence
headache

20
Q

topiramate adverse reactions

A
  • paresthesia
  • weight loss
  • psychomotor slowing
21
Q

tiagabine adverse reactions

A
  • somnolence
  • nausea
  • tremor
  • weight gain
22
Q

zonisamide adverse reactions

A
  • paresthesia
  • dizziness
  • ataxia
  • weight loss
23
Q

oxcarbazepine adverse reactions

A
  • rash
  • dizziness
  • fatigue
  • nausea
24
Q

levetiracetam adverse reactions

A
  • depression
  • dizziness
  • headache
  • drowsiness
25
Q

pregabalin adverse reactions

A
  • weight gain
  • blurry vision
  • dizziness
  • sleepiness
26
Q

diazepam adverse reactions

A
  • drowsiness
  • dizziness
  • fatigue
27
Q

phenobarbital adverse reactions

A
  • changes in sexual function
  • drowsiness
  • irritability
  • loss of coordination
28
Q

valproate MoA

A
  • blocks voltage gated Na channels
  • enhance GABA transamission
  • modulates Ca channels
29
Q

ethosuximide MoA

A

-blocks low threshold Ca channels

30
Q

topiramate MoA

A
  • blocks high frequency voltage gated Na-channels
  • increases Cl opening frequency via GABA
  • antagonizes glutamate action
31
Q

vigabatrin MoA

A

irreversibly inhibits GABA transaminase (GABA degradation)

32
Q

vigabatrin adverse effects

A
  • irreversible concentric visual loss
  • weight gain
  • drowsiness
  • headache
  • memory problems
33
Q

perampanel adverse effects

A
  • mood or behavioral changes
  • weight gain
  • dizziness
34
Q

drugs that cause weight gain

A 
valproic acid
gabapentin
pregabalin
vigabatrin
perampanel
35
Q

drugs that cause weight loss

A

topiramate
zonisamide
felbamate

36
Q

eslicarbazepine adverse effects

A

-rash

37
Q

drugs that cause osteoporosis

A
  • carbamazepine
  • barbituates
  • phenytoin
  • oxcarbazepine
  • valproate
38
Q

drugs that alter connective tissue metabolism

A

phenytoin

phenobarbital

39
Q

drugs that cause neuropathy

A

phenytoin

carbamazepine

40
Q

ezogabine adverse effects

A
  • retinal pigment changes, blue discoloration of skin, sclera and nails
  • may lead to vision loss
41
Q

valproic acid teratogen effect

A

oral cleft, neural tube defects, hypospadias, cardiac malformations, polydactyly

42
Q

carbamazepine teratogen effect

A

neural tube defects

43
Q

phenobarbital teratogen effect

A

cardiac malformation

44
Q

drugs that cause oral cleft defect

A
  • phenytoin
  • phenobarbital
  • carbamazepine
  • tipiramate
  • valproic acid
45
Q

felbamate MoA

A
  • blocks voltage gated Na channels at high firing frequency

- modulates NMDA and GABA receptors

46
Q

felbamate side effects

A

aplastic anemia

weight loss

47
Q

ezogabine MoA

A

K channel opener

PT2 Neuro 1-5 (4 decks)

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