Drug reactions Flashcards

1
Q

Causes of coronary vasospasm

A

Cocaine, sumatriptan (serotonin agonist for cluster headaches/migraines), ergot alkaloids

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2
Q

Causes of cutaneous flushing

A

Vancomycin, Adenosine, Niacin, Ca 2+ channel blockers

VANC

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3
Q

Causes of Dilated cardiomyopathy

A

Doxorubicin (Adriamycin), Daunorubicin

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4
Q

Causes of Torsade de Pointes

A
Class III (sotalol)
Class IA (quinidine)
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5
Q

Causes of agranulocytosis

A

Clozapine, Carbamazepine, Colchicine, PTU, Methimazole, Dapsone

“Agranulocytosis Could Certainly Cause Pretty Major Damage”

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6
Q

Causes of aplastic anemia

A

Chloramphenicol, Benzene, NSAIDs, PTU, Methimazole

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7
Q

Direct Coombs - Positive Hemolytic Anemia

A

Methyldopa, penicillin

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8
Q

Gray baby syndrome

A

Chloramphenicol

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9
Q

Hemolysis in G6PD patients

A

Isoniazid, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

Hemolysis IS PAIN

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10
Q

Megaloblastic anemia

A

Pheytoin, Methotrexate, Sulfa drugs

Having a blast with PMS

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11
Q

Thrombotic complications

A

OCPs

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12
Q

C/O Cough

A

ACEi (use ARB instead)

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13
Q

C/O Pulmonary fibrosis

A

BLeomycin, Amiodarone, Busulfan

“It’s hard to BLAB when you have pulmonary fibrosis”

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14
Q

C/O Acute Cholestatic Hepatitis, Jaundice

A

Erythromicin

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15
Q

C/O Focal to Massive Hepatic Necrosis

A

Halothane, Amanita phalloides (death cap mushroom), Valproic Acid, Acetaminophen

Liver “HAVAc”

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16
Q

C/O Hepatitis

A

INH

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17
Q

C/O Pseudomembranous colitis

A

Clindamycin, ampicillin

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18
Q

C/O Adrenocortical insufficiency

A

Glucocorticoid withdrawal (HPA Suppression)

19
Q

C/O Gynecomastia

A

Spirnolactone (inhibits steroid binding), Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole (inhibits desmolase in steroid synthesis)

“Some Drugs Create Awkward Knockers”

20
Q

C/O Hot flushes

A

Tamoxifen, clomiphene

21
Q

C/O Hyperglycemia

A

Niacin, Tacrolimus, Protease Inhibitors, Hydrachlorathiazide, corticosteroids

22
Q

C/O Hypothyroidism

A

Lithium, Amiodarone, Sulfonamides

23
Q

C/O Fat Redistribution

A

Glucocorticoids, Protease Inhibitors

24
Q

C/O Gingival hyperplasia

A

Phenytoin, verapamil

25
Q

C/O Gout

A

Furosemide, thiazides, niacin, cyclosporine

26
Q

C/O Myopathies

A

Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-alpha, Penicillamine, Statins, Glucocorticoids

Fish N CHIPS Give you myopathies

27
Q

C/O Osteoporosis

A

Corticosteroids, heparin

28
Q

C/O Photosensitivity

A

Sulfonamides, Amiodarone, Tetracycline

SAT for a photo

29
Q

Rash (Stevens-Johnson)

A

Penicillin, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital

Bad rash after a PEC SLAPP

30
Q

SLE-like syndrome

A

Hydralazine, INH, Procainamide, Pheyntoin

It’s not HIPP to have lupus

31
Q

C/O teeth (kids)

A

Tetracyclines

32
Q

C/O tendonitis, tendon rupture, and cartilage damage

A

Fluoroquinolones

33
Q

C/O DI

A

Lithium, demeoclocycline, hypercalcemia

34
Q

C/O Fanconi’s syndrome

A

Expired tetracycline

35
Q

C/O Hemhorrhagic cystitis

A

Cyclophophamide, ifosfamide (prevent by coadministering with mesna)

36
Q

C/O Interstitial nephritis

A

Methicillin, NSAIDs, furosemide

37
Q

C/O SIADH

A

Carbamazepine, cyclophosphamide

38
Q

C/O Cinchonism ( flushed and sweaty skin, ringing of the ears (tinnitus), blurred vision, impaired hearing, confusion, reversible high-frequency hearing loss, headache, abdominal pain, rashes,)

A

Quinidine, quinine

39
Q

C/O Parkinson-like syndrome

A

Antipsychotics, reserpine, metoclopramide

40
Q

C/O Seizures

A

Isoniazid, Bupropion, Imipenem/cilastatin, Tramadol, Enflrane, Metoclopramide

With seizures, I BITE My tongue

41
Q

C/O Tardive dyskinesia

A

Antipsychotics

42
Q

Antimuscarinic Effects

A

Atropine, TCAs, H1-blockers, neuroleptics

43
Q

Disulfuram-like reaction

A

Metronidazole, certain cephalosporins, procarbazine, 1st-generation sulfonylureas

44
Q

Nephrotoxicity/ototoxicity

A

Aminoglycosides, Vancomycin, Loop diuretics, Cisplatin