Drug reactions

Question 1

Causes of coronary vasospasm

Answer 1

Cocaine, sumatriptan (serotonin agonist for cluster headaches/migraines), ergot alkaloids

Question 2

Causes of cutaneous flushing

Answer 2

Vancomycin, Adenosine, Niacin, Ca 2+ channel blockers

VANC

Question 3

Causes of Dilated cardiomyopathy

Answer 3

Doxorubicin (Adriamycin), Daunorubicin

Question 4

Causes of Torsade de Pointes

Answer 4

Class III (sotalol)
Class IA (quinidine)

Question 5

Causes of agranulocytosis

Answer 5

Clozapine, Carbamazepine, Colchicine, PTU, Methimazole, Dapsone

“Agranulocytosis Could Certainly Cause Pretty Major Damage”

Question 6

Causes of aplastic anemia

Answer 6

Chloramphenicol, Benzene, NSAIDs, PTU, Methimazole

Question 7

Direct Coombs - Positive Hemolytic Anemia

Answer 7

Methyldopa, penicillin

Question 8

Gray baby syndrome

Answer 8

Chloramphenicol

Question 9

Hemolysis in G6PD patients

Answer 9

Isoniazid, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

Hemolysis IS PAIN

Question 10

Megaloblastic anemia

Answer 10

Pheytoin, Methotrexate, Sulfa drugs

Having a blast with PMS

Question 11

Thrombotic complications

Answer 11

OCPs

Question 12

C/O Cough

Answer 12

ACEi (use ARB instead)

Question 13

C/O Pulmonary fibrosis

Answer 13

BLeomycin, Amiodarone, Busulfan

“It’s hard to BLAB when you have pulmonary fibrosis”

Question 14

C/O Acute Cholestatic Hepatitis, Jaundice

Answer 14

Erythromicin

Question 15

C/O Focal to Massive Hepatic Necrosis

Answer 15

Halothane, Amanita phalloides (death cap mushroom), Valproic Acid, Acetaminophen

Liver “HAVAc”

Question 16

C/O Hepatitis

Answer 16

INH

Question 17

C/O Pseudomembranous colitis

Answer 17

Clindamycin, ampicillin

Question 18

C/O Adrenocortical insufficiency

Answer 18

Glucocorticoid withdrawal (HPA Suppression)

Question 19

C/O Gynecomastia

Answer 19

Spirnolactone (inhibits steroid binding), Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole (inhibits desmolase in steroid synthesis)

“Some Drugs Create Awkward Knockers”

Question 20

C/O Hot flushes

Answer 20

Tamoxifen, clomiphene

Question 21

C/O Hyperglycemia

Answer 21

Niacin, Tacrolimus, Protease Inhibitors, Hydrachlorathiazide, corticosteroids

Question 22

C/O Hypothyroidism

Answer 22

Lithium, Amiodarone, Sulfonamides

Question 23

C/O Fat Redistribution

Answer 23

Glucocorticoids, Protease Inhibitors

Question 24

C/O Gingival hyperplasia

Answer 24

Phenytoin, verapamil

Question 25

C/O Gout

Answer 25

Furosemide, thiazides, niacin, cyclosporine

Question 26

C/O Myopathies

Answer 26

Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-alpha, Penicillamine, Statins, Glucocorticoids Fish N CHIPS Give you myopathies

Question 27

C/O Osteoporosis

Answer 27

Corticosteroids, heparin

Question 28

C/O Photosensitivity

Answer 28

Sulfonamides, Amiodarone, Tetracycline SAT for a photo

Question 29

Rash (Stevens-Johnson)

Answer 29

Penicillin, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital Bad rash after a PEC SLAPP

Question 30

SLE-like syndrome

Answer 30

Hydralazine, INH, Procainamide, Pheyntoin It's not HIPP to have lupus

Question 31

C/O teeth (kids)

Answer 31

Tetracyclines

Question 32

C/O tendonitis, tendon rupture, and cartilage damage

Answer 32

Fluoroquinolones

Question 33

C/O DI

Answer 33

Lithium, demeoclocycline, hypercalcemia

Question 34

C/O Fanconi's syndrome

Answer 34

Expired tetracycline

Question 35

C/O Hemhorrhagic cystitis

Answer 35

Cyclophophamide, ifosfamide (prevent by coadministering with mesna)

Question 36

C/O Interstitial nephritis

Answer 36

Methicillin, NSAIDs, furosemide

Question 37

C/O SIADH

Answer 37

Carbamazepine, cyclophosphamide

Question 38

C/O Cinchonism ( flushed and sweaty skin, ringing of the ears (tinnitus), blurred vision, impaired hearing, confusion, reversible high-frequency hearing loss, headache, abdominal pain, rashes,)

Answer 38

Quinidine, quinine

Question 39

C/O Parkinson-like syndrome

Answer 39

Antipsychotics, reserpine, metoclopramide

Question 40

C/O Seizures

Answer 40

Isoniazid, Bupropion, Imipenem/cilastatin, Tramadol, Enflrane, Metoclopramide With seizures, I BITE My tongue

Question 41

C/O Tardive dyskinesia

Answer 41

Antipsychotics

Question 42

Antimuscarinic Effects

Answer 42

Atropine, TCAs, H1-blockers, neuroleptics

Question 43

Disulfuram-like reaction

Answer 43

Metronidazole, certain cephalosporins, procarbazine, 1st-generation sulfonylureas

Question 44

Nephrotoxicity/ototoxicity

Answer 44

Aminoglycosides, Vancomycin, Loop diuretics, Cisplatin