Drug quiz 5 errthing

Question 1

Brand: Subutex
Generic: buprenophine

Answer 1

Class: Analgesic, opioid
Dose: 16 mg
ROA: SL
Indication: Opiod dependence
MOA: partial opiod agonist/antagonist. Partial agonist at the mu-opiod receptor and an antagonist at the kappa-opiod receptor.

Question 2

Brand: Fioricet
Generic: butalbital, acetaminophen and caffeine

Answer 2

Class: Barbiturate
Dose: 1-2 Tab Q4H (don’t exceed 6 tab/day)
ROA: PO
Indication: tension headache
MOA: acetaminophen inhibits PG syn and peripheral, butalbital - sensory cortex depression via inhib of conduction in the reticular formation, caffeine - CNS stimulation by inhib of phosphodiesterase which inc the accumulation of cAMP

Question 3

Brand: Colcrys
Generic: colchicine

Answer 3

Class: Antigout agent
Dose: 1 - 2 Tabs Q1-2H PRN 
ROA:  PO 
indication: gout
MOA: binds to microtubular protein which leads to inhibition of the migration of granulocytes into the inflammed area.

Question 4

Brand: Dexilant
Generic: dexlansoprazole

Answer 4

Class: Proton pump inhibitor
Dose: 30 mg QD 
ROA: PO
indication: GERD, heartburn
MOA: inhibits the H+/K+ ATPase enz system at the secretory surface of the gastric parietal cell

Question 5

Brand: Voltaren Gel
Generic: Diclofenac Sodium (topical)

Answer 5

Class: NSAID
Dose: apply 2 g upper extremity/ 4 g lower extremity
ROA: topical
indication: relief joint pain
MOA: exact MOA is unknown, possible inhibition of COX

Question 6

Brand: Lomotil
Generic: diphenoxylate HCl with Atropine Sulfate

Answer 6

Class: Antidiarrheal	
Dose: 2 tabs or 2 tsp up to QID
indication: diarrhea
ROA: PO
MOA: binds to intestinal opiate receptors decreasing peristalsis and affecting water and electrolyte movement

Question 7

Brand: Dilaudid
Generic: hydromorphone HCl

Answer 7

Class: Analgesic, opioid
Dose: 2 - 4 mg Q4-6H	
ROA: PO
indication: pain mgmt	
MOA: pure opiod agonist

Question 8

Brand: Levsin, Levbid
Generic: hyoscyamine Sulfate

Answer 8

Class: Anticholinergic agent
Dose: 0.125-0.25 mg Q4H PRN
ROA: PO
indication: GI antispasmatic (peptic ulcer, IBS, etc
MOA: inhibits the muscarinic action of acetylcholie on the smooth muscle

Question 9

Brand: Indocin
Generic: indomethacin

Answer 9

Class: NSAID)
Dose: 25 - 50 mg BID to TID (200 mg)
ROA: PO
indication:  severe OA or RA pain
MOA: inhibition of COX resulting in a decreased biosynthesis or prostaglandins

Question 10

Brand: Kristalose, Enulose
Generic: lactulose

Answer 10

Class: Laxative, osmotic
Dose: 10 - 20 gm per day 
ROA: PO
indication:  constipation
MOA: broken down into lactic acid, increases osmotic pressure and a pH elevation in the colon

Question 11

Brand: Lidoderm
Generic: lidocaine (Transdermal)

Answer 11

Class: Analgesic, topical
Dose: apply patch to painful area for 12 hrs w/in a 24 hr period
ROA: topical
indication: post-herpetic neuralgia
MOA: neuronal mbr-stabilizing properties by combining w/ fast sodium channels during their inactive state to inhibit repolarization

Question 12

Brand: Amitiza
Generic: lubiprostone

Answer 12

Class: Gastrointestinal agent
Dose: 8 mcg BID w/ food and water
ROA: PO
indication:  IBS	
MOA: chloride channel activator which increases chloride-rich intestinal fluid secretion w/o altering serum sodium or potassium; activated CIC-2 in the apical mbr of the intestine

Question 13

Brand: Pentasa, Asacol HD, Lialda, Delzicol
Generic: mesalamine (oral)

Answer 13

Class: 5-aminosalicylic acid derivative
Dose: 2.4-4.8 g QD
ROA: PO
indication:  ulcerative colitis
MOA: blocks COX and inhibits PG formation which decreased the formation of arachiodonic acid metabolites

Question 14

Brand: Skelaxin
Generic: metaxalone

Answer 14

Class: Skeletal muscle relaxant
Dose: 800 mg TID/QID 
ROA: PO
indication: muscle relaxant
MOA: CNS depressant effects, no direct action on the muscle

Question 15

Brand: Relafen
Generic: nabumetone

Answer 15

Class: NSAID
Dose: maintenance 500 - 2000 mg QD (1 or 2 doses)
ROA: PO
indication: NSAID
MOA: halts prostaglandin synthesis, antiinflammatory, analgesic, and antipyretic properties

Question 16

Brand: Anaprox
Generic: naproxen sodium

Answer 16

Class: NSAID
Dose: 550 mg initi. then 275 mg Q6-8H
ROA: PO
indication: NSAID 
MOA: inhibits COX resulting in decreased biosynthesis of PG

Question 17

Brand: Norflex
Generic: orphenadrine citrate

Answer 17

Class: Skeletal muscle relaxant
Dose: 100 mg BID
ROA: PO
indication:  muslce relaxant
MOA: centrally acting antimuscarinic agent w/ analgesic and anticholinergic properties

Question 18

Brand: Pyridium
Generic: phenazopyridine hydrochloride

Answer 18

Class: Analgesic, urinary
Dose: 200 mg TID PC (after meals)
ROA: PO
indication: urinary tract
MOA: excreted in the urine where it exerts a topical analgesic effect on the urinary tract mucosa, exact MOA unknown

Question 19

Brand: Feldene
Generic: piroxicam

Answer 19

Class: NSAID
Dose: 20 mg QD in sing/div doses 
ROA: PO
indication:  OA or RA pain
MOA: inhibition of COX resulting in a decreased biosynthesis or prostaglandins

Question 20

Brand: Mexalt
Generic: rizatriptan benzoate

Answer 20

Class: Antimigraine, serotonin 5-HT 1 receptor agonist
Dose: 5-10 mg at 1st sign of migraine
ROA: PO
indication: migraine
MOA: selective agonist for vascular 5-hydroxytryptamine 1 receptor and 5-HT1 receptor, vasoconstriction

Question 21

Brand: Carafate
Generic: sucralfate

Answer 21

Class: Gastrointestinal agent
Dose: 1 gm QID on empty stomach
ROA: PO
indication: duodenal ulcer
MOA: formation of an ulcer-adherent complex that covers the ulcer site and protects it against further damage by neutralizing gastric acid

Question 22

Brand: Ultracet
Generic: tramadol hydrochloride with acetaminophen

Answer 22

Class: Analgesic 	
Dose: 2 tab Q4-6H prn for pain	
ROA: PO
indication: pain mgmt
MOA: binding to m-opiod receptors and inhibition of reuptake of NE an dserotonin and acetaminophen inhibits PG synthesisin the CNS