Drug Delivery Modified release (5 lectures)

Question 1

State two pros of modified release dosage forms

Answer 1

maintenance of therapeutic effect overnight

reduction of total amount of drug administered over the period of treatment

Question 2

define: Sustained release. How does it differ from prolonged release.

Answer 2

maintain the rate of drug release over a sustained period. prolonged release referred to drug absorption over a long period of time

Question 3

Define controlled release

Answer 3

also having a sustained release profile but maintaining a predicable plasma concentration that is independent of external environment of the system

Question 4

Diffusion based systems are a form of modified release. what are their subtypes called?

Answer 4

Matrix Devices and Reservoir Devices

Question 5

state the nature of the polymer membrane in a Reservoir device

Answer 5

insoluble but porous hence drug can dissolve through

Question 6

State features of a dissolution based system

Answer 6

soluble membrane.

drug release is controlled by the rate of the membrane dissolving

Question 7

Features of a Matrix device

Answer 7

drug dissolved or dispersed in a water insoluble polymer matrix. As drug dissolved, the matrix is emptied