Drug AEs and DDIs

Question 1

Coronary vasospasm

Answer 1

Cocaine
Sumatriptan
Ergot alkaloids

Question 2

Cutaneous flushing

Answer 2

Vancomycin
Adenosine
Niacin
Ca channel blockers
(mnemonic=VANC)

Question 3

Dilated cardiomyopathy

Answer 3

Anthracyclines (esp doxorubicin & daunorubicin)

Question 4

Torsades de pointes

Answer 4

Class III (sotalol) and class IA (quinidine) antiarrhythmics

Question 5

Agranulocytosis

Answer 5

Clozapine
Carbamazepine
Colchicine
Propylthiouracil
Methimazole
Dapsone
(mnemonic=Agranulocytosis Could Certainly Cause Pretty Major Damage)

Question 6

Aplastic anemia

Answer 6

Chloramphenicol
Benzene
NSAIDs
Propylthiouracil
Methimazole

Question 7

Direct Coombs positive anemia

Answer 7

Methyldopa

Penicillin

Question 8

Gray baby syndrome

Answer 8

Chloramphenicol

Question 9

Gray-blue people (smurfs!)

Answer 9

Amiodarone

Question 10

Hemolysis in G6PDH-deficient patients

Answer 10

Isoniazid (INH)
Sulfonamides
Primaquine
Aspirin
Ibuprofin
Nitrofurantoin
(mnemonic=Hemolysis IS PAIN)

Question 11

Megaloblastic anemia

Answer 11

Phenytoin
Methotrexate
Sulfa drugs (mnemonic=Having a blast with PMS)

Question 12

Thrombotic complications

Answer 12

OCPs (ex: estrogen)

Question 13

Cough

Answer 13

ACE inhibitors (main reason for change to ARBs)

Question 14

Pulmonary fibrosis

Answer 14

Bleomycin
Amiodarone
Busulfan
(mnemonic=It’s hard to BLAB when you have plum fibrosis)

Question 15

Acute cholestatic hepatitis, jaundice

Answer 15

Erythromycin

Question 16

Focal to massive hepatic necrosis

Answer 16

Halothane
Amanita phalloides
Valproic acid
Acetaminophen
(mnemonic=Liver "HAVAc)

Question 17

Hepatitis

Answer 17

INH

Question 18

Pseudomembranous colitis

Answer 18

Clindamycin

Ampicillin

Question 19

Adrenocortical insufficiency

Answer 19

Glucocorticoid withdrawal (HPA suppression)

Question 20

Gynecomastia

Answer 20

Spironolactone
Digitalis
Cimetidine
chronic Alcohol use
Estrogens
Ketoconazole
(mnemonic=Some Drugs Create Awkward Knockers)

Question 21

Hot flashes

Answer 21

Tamoxifen

Clomiphene

Question 22

Hyperglycemia

Answer 22

Niacin
Tacrolimus
Protease inhibitors
HCTZ
Corticosteroids

Question 23

Hypothyroidism

Answer 23

Lithium
Amiodarone
Sulfonamides

Question 24

Fat redistribution

Answer 24

Glucocorticoids

Protease inhibitors

Question 25

Gingival hyperplasia

Answer 25

Phenytoin | Verapamil

Question 26

Gout

Answer 26

Furosemide Thiazides Niacin Cyclosporine

Question 27

Myopathies

Answer 27

``` Fibrates Niacin Colchicine Hydroxychloroquine IFN-alpha Penicillamine Statins Glococorticoids (mnemonic=Fish N CHIPS Give you myopathies) ```

Question 28

Osteoporosis

Answer 28

Corticosteroids | Heparin

Question 29

Photosensitivity

Answer 29

Sulfonamides Amiodarone Tetracycline (SAT for a photo)

Question 30

Rash (stevens-johnson syndrome)

Answer 30

``` Penicillin Ethosuximide Carbamazepine Sulfa drugs Lamotrigine Allopurinol Phenytoin Phenobarbital (Bad rash after a PEC SLAPP) ```

Question 31

SLE-like syndrome

Answer 31

``` Hydralazine INH Procainamide Phenytoin (It's not HIPP to have lupus) ```

Question 32

Teeth (kids)

Answer 32

Tetracyclines

Question 33

Tendonitis, tendon rupture, and cartilage damage

Answer 33

Fluoroquinolones

Question 34

Diabetes insipidus

Answer 34

Lithium | Demeclocycline

Question 35

Fanconi's syndrome

Answer 35

Expired tetracycline

Question 36

Hemorrhagic cystitis

Answer 36

Cyclophosphamide Ifosamide (prevent by giving w/ Mesna)

Question 37

Interstitial nephritis

Answer 37

Methicillin NSAIDs Furosemide

Question 38

SIADH

Answer 38

Carbamazepine | Cyclophosphamide

Question 39

Cinchonism

Answer 39

Quinidine | Quinine

Question 40

Parkinson-like syndrome

Answer 40

Antipsychotics Reserpine Metoclopramide

Question 41

Seizures

Answer 41

``` Isoniazid Bupropion Imipenem/cilastatin Tramadol Enflurane Metoclopramine (with seizures, I BITE My tongue) ```

Question 42

Tardive dyskinesia

Answer 42

Antipsychotics

Question 43

Antimuscarinic

Answer 43

Atropine TCAs H1-blockers Neuroleptics

Question 44

Disulfiram-like rxn

Answer 44

Metronidazole Some cephalosporins Procarbazine 1st gen sulfonylureas

Question 45

Nephrotoxicity/ototoxicity

Answer 45

Aminoglycosides Vancomycin Loop diuretics Cisplatin

Question 46

P450 Inducers

Answer 46

``` Modafinil Barbiturates St. John's wort Phenytoin Rifampin Griseofulvin Carbamazepine Chronic alcohol use (Momma Barb Steals Phen-phen and Refuses Greasy Carbs ChronicAlly) ```

Question 47

P450 inhibitors

Answer 47

``` Macrolides Amiodarone Grapefruit juice Isoniazid Cimetidine Ritonavir Acute alcohol abuse Ciprofloxacin Ketoconazole Sulfonamides Gemfibrozil Quinidine (MAGIC RACKS in GQ) ```

Question 48

List the sulfa drugs

Answer 48

``` Probenecid Furosemide Acetazolamide Celecoxib Thiazides Sulfonamide antibiotics Sulfasalazine Sulfonylureas (Popular FACTSSS) ```

Question 49

AEs with sulfa drugs?

Answer 49

``` Fever UTI Pruritic rash SJS Hemolytic anemia Thrombocytopenia Agranulocytosis Urticaria Symptoms range from mild to life-threatening ```