Drug Absorption and Distribution Flashcards
1
Q
What the drug does to the host
A
Pharmacodynamics
2
Q
What the host does to the drug
A
Pharmacokinetics
3
Q
ADME =
A
absorption, distribution, metabolism, and excretion
4
Q
The plasma concentration and duration of time that a drug has in the body is determined by its:
A
- route of administration and rate of absorption
- distribution to sites of action and elimination
- rate of elimination
5
Q
Drug dose is usually proportional to the…
A
intensity and duration of the drug’s clinical effect
6
Q
The plasma concentration of a drug at any time point following its administration to an animal is determined by its…
A
- absorption
- distribution
- metabolism
- excretion
7
Q
Routes of drug administration
A
- Intravascular (intravenous/intra-arterial)
- Extravascular (oral; subcutaneous; intraperitoneal; intramuscular; inhalation etc.)
- Regional (epidural; topical; nebulization into airway etc.)
8
Q
Intravenous route
A
- most common route
- prompt and predictable control of plasma drug concentration.
- good gor drugs injurious to tissues due to rapid dilution
- good for unconscious or vomiting
- initially high PDC may produce adverse effects
- asepsis required
