DOACs and Heparins

Question 1

What monitoring is required for DOACs

Answer 1

None

Question 2

Apixaban VTE treatment doses

Answer 2

10mg BD for 7 days
=>
5mg BD long term

Question 3

Rivaroxaban VTE treatment doses

Answer 3

15mg BD for 3 weeks
=> 20mg OD long term
(with food)

Question 4

Dabigatran VTE treatment doses

Answer 4

(18 to 74 years)
150mg BD

(75-79 years)
110 to 150mg BD

(80 years +)
110mg BD

Question 5

Edoxaban VTE treatment doses

Answer 5

60mg OD

(under 61kg)
30mg OD

Question 6

What electrolyte imbalance can all Heparins cause

Answer 6

Hyperkalaemia

Question 7

How to treat a heparin associated haemorrhage

Answer 7

Protamine Sulphate (antidote)

Question 8

Characteristics of Unfractionated Heparin

Answer 8

Quick initiation and elimination

Question 9

What does Unfractionated Heparin have a higher risk of than LMWH

Answer 9

heparin induced thrombocytopenia

Question 10

Which Heparin is preferred in Pregnancy

Answer 10

LMWH

Question 11

Which heparin is preferred in renal impairment

Answer 11

Unfractionated

Question 12

What CrCl should Edoxaban not be taken in

Answer 12

below 15

Question 13

What should the INR be when bridging LMWH with Warfarin

Answer 13

once 2 consecutive INR readings of >2 have been reached