DISEASE-MODIFYING ANTIRHEUMATIC DRUGS

Question 1

Methotrexate

Action

Answer 1

Methotrexate is a folic acid antagonist that inhibits cytokine production and purine nucleotide biosynthesis, leading to immunosuppressive and anti-inflammatory effects

Question 2

Uses

Answer 2

has become a mainstay of treatment in patients with rheumatoid or psoriatic arthritis

Question 3

Side effects

Answer 3

The most common side effects observed after methotrexate treatment of RA are mucosal ulceration and nausea. Cytopenias (particularly depression of the WBC count), cirrhosis of the liver, and an acute pneumonia-like syndrome may occur with chronic administration

Question 4

Side effects DDDDDDDecrease HOW????

Answer 4

Taking leucovorin (folinic acid) once daily after methotrexate reduces the severity of adverse effects

Question 5

Hydroxychloroquine

Uses

Answer 5

used for early, mild RA, often combined with methotrexate

Question 6

Side effects

Answer 6

ocular toxicity, including irreversible retinal damage and corneal deposits. It may also cause CNS disturbances, GI upset, and skin discoloration and eruptions.