Diffuse Alveolar Damage Syndrome (DADS) (pathology)

Question 1

What is diffuse alveolar damage syndrome (DADS)?

Answer 1

Acute response to interstitial lung injury

Question 2

What is the clinical name of DADS?

Answer 2

Acute interstitial pneumonitis

Question 3

What are the characteristics of the exudative phase of DADS?

Answer 3

• Protein rich oedema
• Fibrin
• Hyaline membranes
• Denuded BM

Question 4

What are the characteristics of the proliferative phase of DADS?

Answer 4

• epithelial proliferation
• fibroblast proliferation
• scarring

Often die of Type 1 RF before fibrotic stage (hypoxia, normal CO2)

Question 5

What are the causes for DADS (7)?

Answer 5

• major trauma
• chemical injury/toxic inhalation
• circulatory shock
• drug poisoning
• infection (influenza, SARS CoC1/2)
• autoimmune disease
• radiation

can be IDIOPATHIC