Diabetes Medications Flashcards
1
Q
1 st line T2DM
A
Metformin
2
Q
2nd line T2DM
A
Metformin + DPP OR Pioglitazone OR SU OR SGLT
3
Q
3rd line T2DM
A
- triple therapy (metformin + any 2)
- insulin
4
Q
Metformin action
A
decrease insulin resistance
decrease HbA1C
prevents vascular complication
Decrease triglycerides + LDL
5
Q
Metformin side effects
A
GI upset
Rash
Lactic acidosis
Liver failure
6
Q
Metformin class
A
biguanides
7
Q
Sulphonylurea drug name
A
Gliclazide
8
Q
Sulphonylurea action
A
increase insulin from Bcells
prevents microvascular complications
9
Q
Sulphonylurea side effect
A
weight gain
10
Q
Thiazolidinedione (TZD) drug name
A
Pioglitazone
11
Q
TZD (pioglitazone) side effects
A
Increase fractures, HF + cancer
weight gain
NO >65s
12
Q
DDP4 inhibitors drug name
A
Sitagliptin
13
Q
DDP4 inhibitors action
A
blocks enzyme which destroys incretin
14
Q
DDP4 inhibitors side effect
A
HF risk
15
Q
SGLT drug name
A
dapagliflozin
