Diabetes Insulin

Question 1

Regular Insulin

Answer 1

• Rapid, Short acting
• 1 hr, peak=2-4, 5-8 hr duration
• can be give IV

Question 2

NPH(Isophane)

Answer 2

• Slower Absorption
• NOT GIVEN IV
• Duration=18-24
• Glucose control between meals
• DOES NOT REQUIRE AN RX, neither does reg insulin
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Question 3

Lispro(Humalog)

Answer 3

• Less aggregation and more rapid effect than Reg
• shorter duration
• Kinetics similar to endogenous insulin
• less hypoglycemia risk
• GIVEN IV or SubQ
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Question 4

Aspart(Novolog

Answer 4

• Like Lispro, duration=slightly longer
• IV or Sub Q

Question 5

Glulisine(Apidra)

Answer 5

• Like Aspart and Lispro
• AFTER** **meal
• IV and SubQ

Question 6

Glargine(Lantus)

Answer 6

• decreased aggregation
• LONG DURATION, SLOW ABSORPTION
• Peakless, Flat Pharmokinetics
• pH=4, shouldnt be mixed in same syringe as other insulins that have pH=7

Question 7

Detemir(Levemir)

Answer 7

• _ULTRA LONG LASTING _
• Fatty acid chain that binds albumin to prolong action further
• Neutral pH, STILL DONT MIX WITH OTHER INS
• Better and less variable than Glargine
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Question 8

Pramlintide

Answer 8

• Analog of amylin, agonist
• Decrease post meal glucose
• SLOWS GASTRIC emptying, and increase Satiety
  
  • ​Eat less, less glucose to deal with
• WEIGHT LOSS!!!
• Injected SubQ
• Adverse: Nausea, headache, increase risk of hypoglycemia
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