Diabetes Insipidus Flashcards
What is lacked in DI
ADH (Vasopressin, AVP)
What causes ADH secretion
Volume contraction –> increased ECF osmolality –> osmoreceptors stimulated in hypothalamus –> ADH secretion
What does ADH do
Stimulates reabsorption of water in distal tubule and collecting duct –> increased water in ECF and decreased osmolality
What does increased ECF osmolality stimulate
Thirst center –> increased water uptake
If given ADH what is the diagnosis if improved and not improved
Improved - Central
Not Improved - Nephrogenic
What is Central DI caused by
ADH deficiency
What is Nephrogenic DI caused by
Impaired responsiveness of the kidney to ADH
DI is associated with what symptom
PU/PD
What is the drug of choice for CDI in dogs and cats
Desmopressin, DDAVP
How does Desmopressin compare to natural ADH
More potent and longer duration of action
How is desmopressin given
Parenterally (SC, IM or IV)
Nasal drops into conjunctival sac
What is the drug of choice for NDI
Thiazide diuretic
