development of the nervous system

Question 1

debate: diff areas of cortex perform particular functions?

Answer 1

against: goltz observed dogs with parts of brain ablated
for: monkey with damage to one side lost some function

Question 2

morphogen

Answer 2

signalling molecule that produces cellular responses depending on concentration

Question 3

whats constant across different animals?

Answer 3

position of regions
thickness of grey matter

Question 4

what differs across animals?

Answer 4

level of folding (gyrification)

Question 5

roof plate

Answer 5

specifies interneurons
dorsalising morphogens

Question 6

floor plate

Answer 6

specifies motor neurons
ventralising morphogens

Question 7

what determines cell fate?

Answer 7

time and position

Question 8

what happens if you add more morphogen to a particular region?

Answer 8

you get a mirrored region produced

Question 9

ectopic fgf8 results in?

Answer 9

expansion of motor area (rostral -> caudal)

Question 10

hypomorphic fgf8

Answer 10

expansion of visual area (caudal -> rostral)

Question 11

symmetric division

Answer 11

two identical daughter cells

Question 12

asymmetric division

Answer 12

two different daughter cells

Question 13

how do neurons migrate?

Answer 13

deepest layers first

Question 14

barrels (of neurons)

Answer 14

bundle of neurons all receive same input

Question 15

missing / mistargeted thalamocortical axons

Answer 15

late / neonatal: no issue
early embryo: big issue