Dementia 2

Question 1

Pt with vascular dementia has neuropathological changes associated w/

Answer 1

Basal ganglia

Question 2

Med most likely to slow progression of vascular dementia

Answer 2

Aspirin

Question 3

82 y/o has falls, ophthomoplegia, Parkinsonism, and progressive dementia.
Autopsy shows

Answer 3

Tau + neurofibrillary tangles

Question 4

65 y/o w/ disorientation and mild agitation. Vivid VH of children playing in house. 2 similar episodes in past, normal in between episodes. Normal language and memory. Normal CNs. Mild symmetrical rigidity and bradykinesia, no deficits.
MRI, drug screen, and CSF normal.

Answer 4

Dementia w/ Lewy bodies

Question 5

Rationale for using cholinesterase inhibitors in pts with alzheimers

Answer 5

Reduce neuropsych sxs

Question 6

Most important tool for evaluation of early and moderate dementia

Answer 6

MMSE

Question 7

Over several months, 46 y/o pt w/o past psych hx becomes emotionally labeled/irritable. Personality changes, laughs inappropriately when kids taunts stray cat. Within 2 yrs convinced all food has germs. Memory is preserved. No longer to work/live independently. Neuropsych testing shows impaired language/attention.

Answer 7

Frontotemporal dementia

Question 8

Dementia has

Answer 8

Naming deficits

Question 9

Bilateral loss of neurons in CA1 segment of hippocampus is most common histological finding in

Answer 9

Alzheimer’s

Question 10

Pt w/ Alzheimer’s. Pt’s daughter is frustrated w/ having to care for her mother more and is considering removing her from her church group because of it? Initial response?

Answer 10

Tell her to continue going to church group

Question 11

PET scan - bitemporoparietal hypoperfusion in early stages of

Answer 11

Alzheimer’s

Question 12

65 y/o brought in by family for gradual onset and very slow progression of confusion w/ respect to place and time, anomia, slowness of comprehension, neglect of personal hygiene and grooming, apathy, and alterations of personality and behavior, impairment of gait and upright stance, and prominent gasp and suck reflexes.
Dx? Clock drawing test is quickly administered and sensitive screen for?

Answer 12

Frontotemporal dementia or Alzheimer’s

Question 13

65 y/o high school graduate w/ MMSE score of 23. Suggests?

Answer 13

Dementia, mild cognitive impairment

Question 14

Ppl > 40 y/o w/ Down’s frequently develop

Answer 14

Alzheimer’s

Question 15

HIV + w/ memory loss, inattention, lack of motivation, and poor coordination.
Normal LP.
CT - atrophy. MRI - diffuse and confluent white matter changes in T2, w/o any mass effect or gadolinium enhancement.
Dx?

Answer 15

HIV associated dementia

Question 16

Binswanger disease has
1. Pseudobulbar state
2. Gait d/o
3.

Answer 16

3. Dementia

Question 17

Clock drawing test is sensitive for

Answer 17

Alzheimer’s

Question 18

Brain of football player who died by suicide has findings typical of chronic traumatic encephalopathy.
Most typical pathology?

Answer 18

Taupathy

Question 19

54y/o died from rapidly progressive dementia associated w/ myoclonus. Most likely finding at autopsy?

Answer 19

Microvacuolation of glia and neuronal dendrites