DDT Drugs n' Stuff

Question 1

topoisomerase inhibitors

Answer 1

stabilise complex formed w/ DNA + topoisomerase enzyme by binding to it
Forms kink and distorts shape of DNA prevents replication and transcription

Question 2

function of topoisomerase

Answer 2

helps uncoil DNA

Question 3

Examples of topoisomerase inhibitors

Answer 3

Doxorubicin for solid tumours

Question 4

intercalating agents

Answer 4

insert themselves in DNA and distort structure

inhibit replication and transcription

Question 5

Examples of intercalating agents

Answer 5

Dactinomycin for pediatric solid tumour

Question 6

Tubulin inhibitors

Answer 6

tubulin - building blocks of microtubules for mitosis

prevent polymerisation and depolymerisation of microtubules

Question 7

examples of tubulin inhibitors

Answer 7

vincristine - non hodgkins lymphoma and childhood leukemia

paclitaxel - ovarian, breast, lung, bladder etc

Question 8

alkylating agent

Answer 8

electrophilic groups form covalent bonds w/ nucleophilic groups e.g. DNA N-7 guanine
prevent replication and transcription by forming inter/intrastrand cross-linking

Question 9

examples of alkylating agent

Answer 9

chlormethine

Question 10

alkylating agent chlormethine alternative

Answer 10

chlorambucil
melphalan
estramustine
uracil mustard

Question 11

alkylating agent pro drugs

Answer 11

mitomycin C
busulfan 
cyclophosphamide
nitrosourea
CC1065
Tamoxifen

Question 12

alkylating agents chlormethine analogues

Answer 12

chlorambucil
melphalan
urethran
uracil mustard

Question 13

antimetabolites

Answer 13

prevent biosynthesis of normal cell metabolites

based on observation that tumour use uracil to make thymidine

Question 14

examples of antimetabolites

Answer 14

5-Fluorouracil

Question 15

monoclonal antibodies

Answer 15

plasma membrane of cancer cel can have commonly over expressed antigens not seen in normal cell
monoclonal antibodies activate body immune’s response to direct killer cells against tumour

Question 16

what cancer does monoclonal antibodies attack

Answer 16

breast
colrectal
lymphoma

Question 17

examples of monoclonal antibodies

Answer 17

herceptin - HER positive metastatic breast cancer

rituximab - lymphomas and leukemia of B cells attack CD20