Cytokines- First Aid

Question 1

5 cytokines from macrophages

Answer 1

IL1, 6, TNF alpha = acute

these recruit IL 8 & 12

Question 2

2 cytokines secreted by Th1 cell

Answer 2

interferon-gamma, IL2

Question 3

2 cytokines secreted by all T cells

Answer 3

IL2, IL3

Question 4

5 cytokines secreted by Th2 cells

Answer 4

IL4, IL5, IL6, IL10, IL13

Question 5

immune response suppressing cytokines

Answer 5

IL10 & TGF-beta

Question 6

4 functions of IL1 (who secretes?)

Answer 6

macrophage-secreted

1) fever
2) acute inflamm
3) adhesion molecule expression in endothelium
4) chemokine secretion to recruit WBCs

Question 7

2 functions of IL6 (who secretes?)

Answer 7

macrophage-secreted

1) fever
2) acute phase proteins

Question 8

3 functions of TNFalpha (who secretes?)

Answer 8

macrophage-secreted

1) activates endothelium
2) vascular leak
3) WBC recruitment

Question 9

3 functions of IL10 (who secretes?)

Answer 9

Th2-secreted

1) decreases MHC II expression
2) decreases Th1 secreted cytokines
3) inhibits activated macrophages, DCs

Question 10

4 functions of IFN-gamma (who secretes?)

Answer 10

Th1 & NK-secreted

1) inhibits Th2 differentiation
2) stimulates Mphages to phagocytosis
3) activates NK cells to attack virus-infected cells
4) increases MHC expression & antigen presentation

Question 11

function of IL3 (who secretes?)

Answer 11

all T cells

1) acts like GM-CSF, promoting growth & differentiation of bone marrow stem cells

Question 12

2 functions of IL2 (who secretes?)

Answer 12

all T cells

1) increases T cells (Th, CTL, Treg)
2) increases NK cells

Question 13

3 functions of IL4 (who secretes?)

Answer 13

Th2 secretes

1) IgE & IgG class switching
2) increased B cell growth
3) T to Th2 differentiation

Question 14

3 functions of IL5 (who secretes?)

Answer 14

Th2 secretes

1) IgA class switching
2) increased growth/differentiation of B cells
3) growth/diff of eosinophils

Question 15

which cytokines promote B cell growth? who secretes them?

Answer 15

IL4 & IL5 (both from Th2)

Question 16

which cytokines promote fever? who secretes?

Answer 16

IL1 & IL6 (from macrophages)

Question 17

which cytokines promote NK activity? who secretes them?

Answer 17

• IL12 (from macrophages)
• IL2 (from all T cells)
• IFN-gamma (from Th1)
• IFN-beta

Question 18

which cytokines promote eosinophil growth? who secretes?

Answer 18

IL5 (from Th2 cells)

Question 19

which cytokines promote class switching to IgA, IgE, or IgG?

Answer 19

IgA = IL5
IgE & IgG = IL4
Both IL4 and IL5 come from Th2 cells

Question 20

3 cytokines secreted by Treg cells

Answer 20

TGF-beta, IL10, IL35

Question 21

3 cytokines secreted by Th17

Answer 21

IL17, IL21, IL 22

Question 22

broad function of Th1 cells

Answer 22

Activate macrophages & CTLs (kill phagocytosized microbes)

Question 23

broad function of Th2 cells

Answer 23

activates eosinophils, promotes IgE for parasite defense

Question 24

broad function of Treg

Answer 24

maintain tolerance to self-antigens

Question 25

broad function of Th17 cells

Answer 25

Induces neutrophilic inflammation to defend against extracellular microbes