cushings

Question 1

cushings syndrome?

Answer 1

umbrella term that describes cortisol excess

Question 2

presentation of cushings?

Answer 2

central obesity with straie
moon face with plethora
proximal muscle wasting - thin arms and legs
skin - loss of scalp hair, skin thinning, easy bruising
psychiatric - depression, euphoria, psychosis
oligomenorrhoea and amenorrhoea
medical conditions - hypertension, osteoperosis, hyperglycaemia, suceptibility to infection, poor wound healing, oligomennorhoea, amennorrhoea

Question 3

why do you get poor wound healing in cushings?

Answer 3

steroids reduce inflammation

Question 4

what would blood glucose be like?

Answer 4

raised

Question 5

24 hour urinary cortisol?

Answer 5

raised

Question 6

how do you screen for cushings

Answer 6

overnight dexamethasone suppression test

Question 7

diagnostic test for cushings?

Answer 7

48 hour dexamethasone test

Question 8

tests to determine cause of cushings?

Answer 8

CT/MRI head
CT CAP
plasma ACTH

Question 9

if its caused by iatrogenic? management ?

Answer 9

stop steroids

Question 10

pituitary adenoma?

Answer 10

surgical excision

Question 11

adrenal adenoma ?

Answer 11

surgical excision

Question 12

symptomatic control n cushings?

Answer 12

adrenal enzyme inhibitors
metyrapone
ketoconazole