Complement Deficiencies

Question 1

What components and pathway are associated with SLE

Answer 1

Component: C1, C4, C2

Pathway: Classical

Question 2

What components and pathway are associated with pyogenic bacteria

Answer 2

components: MBL, MASP

Pathway: Lectin

Question 3

What component and pathway are associated with Recurrent angioedema

Answer 3

Component: C1-INH

Pathway: Classical pathway regulation

Question 4

What components and pathway are associated with membranoproliferativr glomerulonephritis

Answer 4

Component: Factor H and I acquired C3 deficiency

Pathway: Alternate

Question 5

What components and pathway are associated with Atyptical hemolytic uremic syndrome and age related macular degeneration?

Answer 5

Component: CD46 (MCP) and factor H

Pathway: Membrane regulation

Question 6

What components and pathway are associated with Paroxysmal nocturnal hemoglobinuria?

Answer 6

Components: CD55 (DAF) and CD59

Pathway:Membrane regulation

Question 7

What symptoms are seen in Paroxysmal nocturnal hemoglobinuria?

Answer 7

Destruction of RBC (hemolytic aneima), blood clots (thombosis), impaired bone marrow function (pancytopenia)

Question 8

What symptoms are seen in Atypical hemolytic uremic syndrome (aHUS)

Answer 8

thrombocytopenia, , microangiopathic hemolytic anemia and acute renal failure

Question 9

What symptoms are seen in Hereditary angioedema (HAE)

Answer 9

Edema in varipus parts of body, swelling in intestinal wall leads to abdominal pain, nausea and vomiting, Airway swelling leading to death by asphyxiation

Question 10

What symptoms are seen in Age related macular degeneration?

Answer 10

Disease of the macula (central part of the retina) leading to irreversible visual loss