Common rat strains and research uses Flashcards
ACI
- High incidence of urogenital congenital malformations including renal agenesis, hypoplasia, hydronephrosis or cystic kidney, unilateral, that may be associated with ipsilateral defective uterine horn or testis
- High incidence of testicular tumors
BB/Wor
- Type I DM: juvenile onset
BN
Brown Norway
- Transplantation research: inducible, transplantable myeloid leukemia, bladder carcinoma
- Hydronephrosis
- Genetic mapping, respiratory inflammation, immunological dysfunction, aging
BUF
Buffalo Rat
- Spontaneous autoimmune thyroiditis
- Carcinogenesis & oncology - host for transplantable Morris hepatoma
COP
Copenhagen Rat
- Carcinogenesis research & oncology
- Protate adenocarcinoma
F-344
Fischer 344
- Inbred rat model for National Toxicology Programs Carcinogen Bioassay Program and the National Institute of Aging
- General multipurpose model, aging, safety and efficacy testing, surgical model, oncology, nutrition
- High rate of spontaneous cancer
LEW
Lewis Rat
-
Multiple sclerosis & various experimentally induced autoimmune diseases
- Induced arthritis/inflammation
- Experimental allergic encephalitis
- STZ-induced diabetes
- Transplantation research
LOU/C
- High incidence of myeloma/plasmacytoma
- Production of IgG autoantibody
SHR
What is the control for this rat?
Spontaneous Hypertensive Rat –> WKY is the control strain in studies using SHR
- Hypertension & CV research: genetic hypertension, hypertensive drug research
- ADHD model, safety and efficacy testing
WF
Wistar-Furth
- Mononuclear cell leukemia
- Resistant to chronic renal disease
- Macrothrombocytopenia model
- Oncology & carcinogenesis
- Grand mal seizure
ZDF
Zucker Diabetic Fatty
-
Obese, type II DM & metabolic syndrome
- Obesity
- Insulin resistance (hyperinsulinemia)
- Glucose intolerance (hyperglycemia)
- Dyslipidemia (hypertriglyceridemia, hypercholesterolemia)
- Hypertension
- Nephropathy, impaired wound healing, & neuropathy
Battleboro
- Diabetes insipidus
- autosomal recessive
Gunn
- Jaundice & kernicterus (bilirubin-induced brain injury)
- Lacks UDP glucuronyl transferase in liver
- Model of Crigler-Najjar Syndrome
RNU
What is the genotype & phenotype?
Rowett Nude Rat…aka…Nude Rat, Athymic Rat
- Genotype = Foxn1rnu / Foxn1rnu
- Phenotype = T cell-deficient, B cells & NK cells are present
SHROB
Spontaneously Hypertensive Obese Rat
- Metabolic Syndrome
- Hypertension
- Insulin resistance
- Glucose intolerance
- Obesity
- Hyperlipidemia: Type 4 hyperlipoproteinemia
- Nephropathy
GK (Goto-Kakizaki)
- Non-obese type 2 DM
- Wistar substrain that develops adult onset DM early in life
Zucker
Obesity & metabolic syndrome
Dahl/SS
What is the control for this rat?
Dahl/Salt Sensitive Rat
The SS-13BN is the normotensive control for the Dahl/SS rat
- Hypertension
- Diastolic heart failure
- Nephropathy
.
FHH
Fawn hooded rat
- Hypertension & pulmonary hypertension
- Nephropathy
- Alcohol consumption
LEC
Long Evans Cinnamon
- Model of spontaneous hepatitis and liver cancer d/t abnormal copper metabolism
- Wilson’s Disease
WAG/Rij Rat
Wistar Albino Glaxo Rat
- Bilateral retinal degeneration resembles human retinitis pigmentosa
- L4415 leukaemia in the WAG/Rij is an animal model for the human acute lymphocytic leukaemia
Spotted lethal mutant
- Aganglionic megacolon
- Model of Hirschsprungs Disease in humans
- Similar to Lethal White Syndrome most common in American Paint Horses
- The coat is completely white (unpigmented) except for a pigmented spot on head
LES & LE-bo
Long Evans Shaker & Long Evans Bouncer
Models of dysmyelination
Prone to seizures which can cause hyperflexion of spine leading to acute hindlimb paralysis
LE-bo presents earlier & has a shorter lifespan
WBN/Kob
Wistar Bonn Kobori
Type I diabetic rats that spontaneously develop diabetic peripheral motor neuropathy
