Collagen Synthesis Flashcards
Describe the structural organization of collagen
fibrils -> fibers -> bundles
What type of collagen is most commonly found in bone?
Type I collagen
What type of collagen is most commonly found in cartilage?
Type II collagen
What type of collagen is most commonly found in reticular areas (skin, muscles, blood vessels)?
Type III collagen
What type of collagen is most commonly found in the basement membrane?
Type IV collagen
What type of cell produces collagen and can differentiate into other cells?
Fibroblast
What cells are the LEAST specialized in the body?
fibroblasts
Fibroblasts will differentiate into ____ when the environment is anoxic
chondrocytes (cartilage cell)
What 3 steps of collagen synthesis occur intracellularly?
- amino acid synthesis
- alpha chain formation
- procollagen formation
During collagen synthesis, what materials are necessary for hydroxylation to occur?
Iron, oxygen, and vitamin C
What must occur in order to turn procollagen into tropocollagen?
Cleavage of terminal extensions of procollagen
What enzyme is responsible for the creation of tropocollagen?
Procollagen peptidase
What collagen synthesis disorder is characterized by an issue with the procollagen peptidase enzyme?
Ehlers-Danlos Syndrome (EDS)
What step of collagen synthesis is disrupted in a patient with Scurvy?
Hydroxylation step
What are some of the general clinical manifestations of collagen synthesis disorders?
- Ligamentous laxity
- Joint hypermobility
- Vessel fragility
- compromised structural integrity of bone
- tooth loss/developmental issues
