Cognitive disorders

Question 1

What is subjective cognitive impairment?

Answer 1

everyday forgetfulness impacting on function
often in those with previously good memories
mismatch between symptoms and reported function/ symptoms and symptoms of known neurodegenerative disorders (patient reports worse memory loss than actually is)

Question 2

What is the presentation of subjective cognitive impairment?

Answer 2

decreased attention span
concentration
reaction time

Question 3

What is Prion disease?

Answer 3

a transmittable neurodegenerative disorder

Question 4

What causes prion disease?

Answer 4

abnormality with the prion protein in the brain - causes neurodegeneration
everytime an abnormal prion protein comes into contact with a normal one - it turns abnormal

Question 5

What is the most comon type of Prion disease?

Answer 5

Creutzfeldt Jacobs disease

Question 6

What are the 4 types of CJD?

Answer 6

sporadic
variant
iatrogenic
genetic

Question 7

Describe sporadic CJD?

Answer 7

60yrs onset
rapid onset dementia, neurological signs and myoclonus
4months life expectancy
due to: erroneous production of PrPsc or somatic mutation of PRNP

Question 8

Describe variant CJD?

Answer 8

20yrs onset
very rapid neuropsychiatric decline and painful sensory disturbance
14 months life expectancy
due to: BSE exposure or contaminated food

Question 9

Describe iatrogenic CJD?

Answer 9

30yrs
cerebellar/visual onset
multifocal neurological decline
<2 yrs life expectancy 
due to: injecting growth hormone

Question 10

Describe genetic CJD?

Answer 10

any age of onsey
life expectancy <2 years
due to: mutation of PRNP gene