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Clinical Medicine Master > Coagulation (MR) > Flashcards

Coagulation (MR) Flashcards

1
Q

1º Coagulation involves? What type of hold does this create?

A

Platelets Vasculature Platelet Plug - Temporary Hold

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2
Q

2º Coagulation involves? What type of hold does this create?

A

Coagulation factors Antithrombotic Fibrinolytic Containment

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3
Q

The moment you turn on clotting what else are you turning on? Where? Why?

A

Anticlotting Periphery So your whole body doesn’t clot lol

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4
Q

CX of 1º Hemostatic Disorders?

A

Petechia Ecchymosis Mucosal Bleeds Epistaxis - not nec small

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5
Q

CX of 2º Hemostatic Disorders?

A

Hemoabdomen Hemothorax Melena Hematemesis

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6
Q

What are the 3 corners of Virchow’s Triad? What does it mean?

A

Stasis - ↓ Blood Flow Endothelial Injury (inside of bv) Hypercoagulability Balance of clottiness vs not clottiness

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7
Q

What causes stasis?

A

Venous Obstruction Cardiac Dz Immobility

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8
Q

What causes Endothelial Injury?

A

Trauma, sx Venipuncture Catheters Vasculitis

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9
Q

What causes Hypercoagulability?

A

Almost any dz on the planet Neoplasia Inflammation Trauma/sx MODS Sepsis Clotting Factor abnormality

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10
Q

What does Hypercoagulability lead to?

A

DIC used up all your clotters

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11
Q

Describe platelets? What do they consist of?

A

Megakaryocyte fragments Proteins Glycoproteins Channels Granules

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12
Q

Can you do advanced diagnostic testing on low platelets? Why?

A

NO Because if there are only 4, they could

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13
Q

TQ!!! What is the first test you will ever do on platelets?

A

Platelet count

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14
Q

BMBT stands for?

A

Buccal Mucosal Bleeding Time

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15
Q

Platelet Tests?

A

BMBT Clot Retraction Test

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16
Q

What is Clot Retraction Study diagnostic for? Who is predisposed to this?

A

Glandsmans Thrombinsthenia Great Pyrenees

17
Q

Thromboeslatography?

A

Global Idea of Clotting Activity of the Animal Includes 1º & 2º Hemostasis from the beginning of clot formation through the end of breakdown

18
Q

2º Hemostasis/Clotting Factors is which system?

A

Intrinsic Pathway

19
Q

What is the only soluble clotting factor in extrinsic pathway?

A

7

20
Q

What are the only 2 clotting factors in the extrinsic pathway?

A

7 & 3 (tissue factor)

21
Q

Wal-Mart analogy for Intrinsic Pathway? So, what are the Factors of the Intrinsic Pathway?

A

It’s not $12, it’s $11.98. 12, 11, 9, 8

22
Q

What is Clotting Factor #4?

A

Ca2+

23
Q

What does ACT test basically tell you?

A

Common Pathway Intrinsic, Extrinsic, & Common Clot or No Clot

24
Q

Thrombin Time (TT) Test is a test of?

A

Function of Fibrinogen (corrigan side-note: not a clinically helpful test for her)

25
Q

One Step Prothrombin Time (OSPT)/(PT) tests which pathway(s)?

A

Extrinsic & Common

26
Q

Activated Partial Thromboplastin Time (APTT)/(PTT) is a test of?

A

Intrinsic & Common Pathways

27
Q

Fibrinogen/Fibrin Degradation Products Test (FDP) tests for?

A

Non-specific inflammation breakdown products. Clot Breakdown products. Not that useful clinically

28
Q

D-Dimer tests for? What does this mean?

A

Specific Clot Breakdown 2º Fibrinolysis A clot was formed, and got digested properly.

29
Q

What would coagulation tests most likely look like with DIC?

A

↑ PT, PTT, FDP, and D-Dimers Low platelet count

30
Q

Which factor has very short t1/2? How long?

A

7 4-6 hours

31
Q

TQ!!! What are the Vit K dependent factors?

A

2, 7, 9,10

32
Q

Which clotting factors have a t1/2 of 1 - 2 days (12- 24 hrs)?

A

5, 8, 9, 10

33
Q

Which clotting factors have a t1/2 of 2 - 3 days?

A

1, 2, 11, 12

34
Q

List the Antithrombotic Proteins & Fibrinolytic Proteins?

A

Protein C Protein S Antithrombin Plasminogen - with its activators, inhibitors, & suppressors Urokinase Streptokinase

Clinical Medicine Master (17 decks)

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