Coagulation (MR)

Question 1

1º Coagulation involves? What type of hold does this create?

Answer 1

Platelets Vasculature Platelet Plug - Temporary Hold

Question 2

2º Coagulation involves? What type of hold does this create?

Answer 2

Coagulation factors Antithrombotic Fibrinolytic Containment

Question 3

The moment you turn on clotting what else are you turning on? Where? Why?

Answer 3

Anticlotting Periphery So your whole body doesn’t clot lol

Question 4

CX of 1º Hemostatic Disorders?

Answer 4

Petechia Ecchymosis Mucosal Bleeds Epistaxis - not nec small

Question 5

CX of 2º Hemostatic Disorders?

Answer 5

Hemoabdomen Hemothorax Melena Hematemesis

Question 6

What are the 3 corners of Virchow’s Triad? What does it mean?

Answer 6

Stasis - ↓ Blood Flow Endothelial Injury (inside of bv) Hypercoagulability Balance of clottiness vs not clottiness

Question 7

What causes stasis?

Answer 7

Venous Obstruction Cardiac Dz Immobility

Question 8

What causes Endothelial Injury?

Answer 8

Trauma, sx Venipuncture Catheters Vasculitis

Question 9

What causes Hypercoagulability?

Answer 9

Almost any dz on the planet Neoplasia Inflammation Trauma/sx MODS Sepsis Clotting Factor abnormality

Question 10

What does Hypercoagulability lead to?

Answer 10

DIC used up all your clotters

Question 11

Describe platelets? What do they consist of?

Answer 11

Megakaryocyte fragments Proteins Glycoproteins Channels Granules

Question 12

Can you do advanced diagnostic testing on low platelets? Why?

Answer 12

NO Because if there are only 4, they could

Question 13

TQ!!! What is the first test you will ever do on platelets?

Answer 13

Platelet count

Question 14

BMBT stands for?

Answer 14

Buccal Mucosal Bleeding Time

Question 15

Platelet Tests?

Answer 15

BMBT Clot Retraction Test

Question 16

What is Clot Retraction Study diagnostic for? Who is predisposed to this?

Answer 16

Glandsmans Thrombinsthenia Great Pyrenees

Question 17

Thromboeslatography?

Answer 17

Global Idea of Clotting Activity of the Animal Includes 1º & 2º Hemostasis from the beginning of clot formation through the end of breakdown

Question 18

2º Hemostasis/Clotting Factors is which system?

Answer 18

Intrinsic Pathway

Question 19

What is the only soluble clotting factor in extrinsic pathway?

Answer 19

7

Question 20

What are the only 2 clotting factors in the extrinsic pathway?

Answer 20

7 & 3 (tissue factor)

Question 21

Wal-Mart analogy for Intrinsic Pathway? So, what are the Factors of the Intrinsic Pathway?

Answer 21

It’s not $12, it’s $11.98. 12, 11, 9, 8

Question 22

What is Clotting Factor #4?

Answer 22

Ca2+

Question 23

What does ACT test basically tell you?

Answer 23

Common Pathway Intrinsic, Extrinsic, & Common Clot or No Clot

Question 24

Thrombin Time (TT) Test is a test of?

Answer 24

Function of Fibrinogen (corrigan side-note: not a clinically helpful test for her)

Question 25

One Step Prothrombin Time (OSPT)/(PT) tests which pathway(s)?

Answer 25

Extrinsic & Common

Question 26

Activated Partial Thromboplastin Time (APTT)/(PTT) is a test of?

Answer 26

Intrinsic & Common Pathways

Question 27

Fibrinogen/Fibrin Degradation Products Test (FDP) tests for?

Answer 27

Non-specific inflammation breakdown products. Clot Breakdown products. Not that useful clinically

Question 28

D-Dimer tests for? What does this mean?

Answer 28

Specific Clot Breakdown 2º Fibrinolysis A clot was formed, and got digested properly.

Question 29

What would coagulation tests most likely look like with DIC?

Answer 29

↑ PT, PTT, FDP, and D-Dimers Low platelet count

Question 30

Which factor has very short t1/2? How long?

Answer 30

7 4-6 hours

Question 31

TQ!!! What are the Vit K dependent factors?

Answer 31

2, 7, 9,10

Question 32

Which clotting factors have a t1/2 of 1 - 2 days (12- 24 hrs)?

Answer 32

5, 8, 9, 10

Question 33

Which clotting factors have a t1/2 of 2 - 3 days?

Answer 33

1, 2, 11, 12

Question 34

List the Antithrombotic Proteins & Fibrinolytic Proteins?

Answer 34

Protein C Protein S Antithrombin Plasminogen - with its activators, inhibitors, & suppressors Urokinase Streptokinase