Clinical pharmacokinetic parameters

Question 1

What factors into Vd determination in reality? 3 things

Answer 1

1. constrained to plasma for [drug] determination 2. plasma has drug binding proteins 3. other tissue partitions where some drugs preferentially go

Question 2

Small Vd drug properties: 3 things

Answer 2

1. lipid solubility low 2. high degree of plasma protein binding 3. low level of tissue binding

Question 3

Large Vd drug properties: 3 things

Answer 3

1. high lipid solubility 2. low degree of plasma protein binding 3. high level of tissue binding